Walker J S, Klein F, Lincoln R E, Fernelius A L
J Bacteriol. 1967 Sep;94(3):552-6. doi: 10.1128/jb.94.3.552-556.1967.
Rats, rabbits, swine, guinea pigs, and monkeys were infected with anthrax spores, and their temperature responses were recorded. These were characteristic for a species and appeared independent of resistance or susceptibility of the species toward establishment of the disease. The rabbit appeared unique in that it not only failed to demonstrate a dose-response relationship over an 8-log dose range, but acted independently producing erratic body temperatures depending on spore dose. This limits the usefulness of the rabbit in studying anthrax pathogenesis, and poses questions regarding published data with the rabbit as the test animal.
将大鼠、兔子、猪、豚鼠和猴子感染炭疽芽孢，并记录它们的体温反应。这些反应具有物种特异性，且似乎与该物种对疾病发生的抵抗力或易感性无关。兔子的情况较为独特，它不仅在8个对数剂量范围内未表现出剂量反应关系，而且体温变化不稳定，与芽孢剂量无关。这限制了兔子在研究炭疽发病机制中的用途，也引发了对以兔子为实验动物所发表数据的质疑。
