Abrams R, Taylor M A
Arch Gen Psychiatry. 1979 Nov;36(12):1355-8. doi: 10.1001/archpsyc.1979.01780120085010.
We analyzed the EEGs of 27 schizophrenic patients and 132 patients with affective disorder who received diagnoses according to rigorous research criteria. The proportion of abnormal EEGs was twice as great among schizophrenics as among affectives, and when the groups were compared for localized cortical differences, schizophrenics had more temporal abnormalities and affectives more parieto/occipital abnormalities. There was also a trend toward different hemispheric lateralization for the two groups, with a reversal of the relative proportions of left- and right-sided abnormalities. These differences were unrelated to age, sex, severity of illness, or past or present drug administration. These findings are complementary to those of other workers, lend support to the validity of our diagnostic research criteria, and provide additional evidence for neurophysiological differences between schizophrenics and patients with affective disorder.
我们分析了27例精神分裂症患者和132例情感障碍患者的脑电图，这些患者均根据严格的研究标准进行诊断。精神分裂症患者脑电图异常的比例是情感障碍患者的两倍，当比较两组局部皮质差异时，精神分裂症患者颞叶异常更多，而情感障碍患者顶叶/枕叶异常更多。两组在半球侧化方面也存在不同趋势，左右侧异常的相对比例发生了逆转。这些差异与年龄、性别、疾病严重程度或过去及目前的用药情况无关。这些发现与其他研究人员的结果相辅相成，支持了我们诊断研究标准的有效性，并为精神分裂症患者与情感障碍患者之间的神经生理差异提供了额外证据。
