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用14C-三棕榈酸酯/3H-棕榈酸诊断脂肪吸收

Diagnosis of fat absorption with 14C-tripalmitate/3H-palmitic acid.

作者信息

Adlung J, Grazikowske H

出版信息

Scand J Gastroenterol. 1979;14(5):587-92. doi: 10.3109/00365527909181394.

DOI:10.3109/00365527909181394
PMID:497049
Abstract

In 44 normal subjects, in 89 patients with chronic pancreatitis, of whom 23 had elevated faecal fat, and in 19 patients with various diseases of the small gut investigations with 14C-tripalmitate and 3H-palmitic acid, dissolved in 1.0 g Indian corn oil/kg, were performed. Serum lipid activity of 14C and 3H was measured 4, 6, and 8 h later. Compared with absolute values of triglyceride absorption (percentage dose of 14C-lipid activity/l serum), relative values (14C/3H ratio of the serum lipids) led to a significantly better discrimination between the control group and patients, attributable to a much smaller normal range. Compared with fatty acid absorption, triglyceride absorption was lowered in all cases of pancreatic steatorrhoea, in most cases of chronic pancreatitis, and in some cases of intestinal malabsorption. While the proposed procedure seems to be sensitive and reliable in the detection of maldigestion, a distinction between maldigestion and malabsorption is apparently uncertain.

摘要

对44名正常受试者、89名慢性胰腺炎患者(其中23名粪便脂肪升高)以及19名患有各种小肠疾病的患者,使用溶解于1.0 g/kg玉米油中的14C-三棕榈酸酯和3H-棕榈酸进行了研究。4、6和8小时后测量血清中14C和3H的脂质活性。与甘油三酯吸收的绝对值(14C-脂质活性/升血清的剂量百分比)相比,相对值(血清脂质的14C/3H比值)在区分对照组和患者方面表现明显更好,这归因于正常范围小得多。与脂肪酸吸收相比,在所有胰腺性脂肪泻病例、大多数慢性胰腺炎病例以及一些肠道吸收不良病例中,甘油三酯吸收均降低。虽然所提出的方法在检测消化功能不良方面似乎敏感且可靠,但消化功能不良和吸收不良之间的区分显然并不确定。

相似文献

1
Diagnosis of fat absorption with 14C-tripalmitate/3H-palmitic acid.用14C-三棕榈酸酯/3H-棕榈酸诊断脂肪吸收
Scand J Gastroenterol. 1979;14(5):587-92. doi: 10.3109/00365527909181394.
2
[New procedure in the diagnosis of maldigestion. Studies with 3-H palmitic acid and 14-C tripalmitate in normal subjects and patients with chronic pancreatitis].[消化不良诊断的新方法。对正常受试者和慢性胰腺炎患者进行的3-H棕榈酸和14-C三棕榈酸研究]
Schweiz Med Wochenschr. 1975 Feb 1;105(5):134-40.
3
[Measurement of lipid digestion and lipid absorption with 3H-palmitic acid and 14C-tripalmitate].[用³H-棕榈酸和¹⁴C-三棕榈酸酯测量脂质消化和脂质吸收]
Radiol Diagn (Berl). 1987;28(3):421-5.
4
Serum radioactivity of 14C-triolein and 3H-oleic acid ingested in a test meal:a rapid test of pancreatic exocrine insufficiency.在试餐中摄入的14C-三油酸甘油酯和3H-油酸的血清放射性:胰腺外分泌功能不全的快速检测
Scand J Gastroenterol. 1979;14(5):529-34. doi: 10.3109/00365527909181385.
5
Fat digestion tests.脂肪消化试验。
Digestion. 1987;37 Suppl 1:25-34. doi: 10.1159/000199536.
6
Simultaneous assessment of fat maldigestion and fat malabsorption by a double-isotope method using fecal radioactivity.采用粪便放射性双同位素法同时评估脂肪消化不良和脂肪吸收不良。
Gastroenterology. 1985 Jan;88(1 Pt 1):47-54. doi: 10.1016/s0016-5085(85)80131-1.
7
The glyceryl [14C]tripalmitate breath test: a reassessment.甘油[14C]三棕榈酸酯呼气试验:重新评估
Clin Chim Acta. 1980 May 9;103(3):317-23. doi: 10.1016/0009-8981(80)90150-3.
8
Faecal triglycerides and fatty acids in the differential diagnosis of pancreatic insufficiency and intestinal malabsorption in patients with low fat intakes.
J Int Med Res. 1995 Jan-Feb;23(1):48-55. doi: 10.1177/030006059502300106.
9
The serum 14C-triolein/3H-oleic acid assimilation test for differential diagnosis of maldigestion and malabsorption.血清14C-三油酸甘油酯/3H-油酸同化试验用于消化不良和吸收不良的鉴别诊断。
Scand J Gastroenterol. 1985 Aug;20(6):684-90. doi: 10.3109/00365528509089195.
10
Clinical Experiences in 14C-tripalmitin breath test for fat malabsorption.
Am J Gastroenterol. 1980 Mar;73(3):227-31.

引用本文的文献

1
Metabolism of ingested 14C-triolein. Estimation of radiation dose in tests of lipid assimilation using 14C-and 3H-labelled fatty acids.摄入的14C-三油酸甘油酯的代谢。使用14C和3H标记脂肪酸进行脂质同化试验时辐射剂量的估算。
Eur J Nucl Med. 1981;6(7):327-9. doi: 10.1007/BF00262527.
2
Pancreatic exocrine function testing.胰腺外分泌功能检测
West J Med. 1981 Nov;135(5):368-73.