枯草芽孢杆菌中组氨酸和芳香族氨基酸生物合成酶的阻遏控制中的共同要素。
Common element in the repression control of enzymes of histidine and aromatic amino acid biosynthesis in Bacillus subtilus.
作者信息
Chapman L F, Nester E W
出版信息
J Bacteriol. 1968 Nov;96(5):1658-63. doi: 10.1128/jb.96.5.1658-1663.1968.
Abstract
Single-step mutants of Bacillus subtilis derepressed for enzymes of both aromatic amino acid and histidine biosynthesis were isolated. These mutants occur at a frequency of 10(-6) per cell per generation. All histidine enzymes as well as all enzymes of aromatic acid synthesis which were examined are maximally derepressed. This level cannot be repressed by growth on either histidine or tyrosine. Some of the structural genes which specify the derepressed enzymes are linked to the aromatic cluster; others are unlinked. The significance of these nonrepressible strains is discussed in terms of the mechanism of repression.
摘要
分离出了枯草芽孢杆菌的单步突变体，这些突变体对于芳香族氨基酸和组氨酸生物合成的酶来说是去阻遏的。这些突变体的出现频率为每代每细胞10⁻⁶。所检测的所有组氨酸酶以及所有芳香酸合成酶都被最大程度地去阻遏。在组氨酸或酪氨酸上生长都不能使这种水平受到阻遏。一些编码去阻遏酶的结构基因与芳香族基因簇相连；其他的则不相连。根据阻遏机制讨论了这些不可阻遏菌株的意义。
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