Brezinova V, Calverley P M, Flenley D C, Townsend H R
Bull Eur Physiopathol Respir. 1979 Jul-Aug;15(4):603-9.
A homogeneous sample of 14 patients with advanced chronic bronchitis and emphysema complicated by secondary polycythaemia and pulmonary hypertension was examined. Eight patients who were receiving long-term oxygen therapy (LTO2) for 15-20 h in the 24 h day showed a significantly faster, that is more normal, frequency of the dominant EEG activity and a higher level of arterial oxygenation when breathing air than six similar patients not receiving LTO2. Acute administration of oxygen (2 1/min) for 15 min did not change the EEG pattern in either group of patients. The frequency of the dominant EEG activity in all 14 patients showed a significant positive correlation with the arterial oxygen saturation and negative correlation with the level of polycythaemia. Occurrence of intermixed EEG show activity theta and delta was positively correlated both with hypoxaemia and hypercapnia. The results suggest that the LTO2 in patients with chronic ventilatory failure has a beneficial effect on cerebral function as measured by EEG.
对14例晚期慢性支气管炎、肺气肿合并继发性红细胞增多症和肺动脉高压患者的同质样本进行了检查。8例患者每天24小时接受15 - 20小时的长期氧疗（LTO2），与6例未接受LTO2的类似患者相比，在呼吸空气时，其脑电图（EEG）主导活动频率明显更快，即更接近正常，且动脉氧合水平更高。两组患者急性给予氧气（2升/分钟）15分钟均未改变EEG模式。所有14例患者的EEG主导活动频率与动脉血氧饱和度呈显著正相关，与红细胞增多水平呈负相关。EEG中出现θ波和δ波混合活动与低氧血症和高碳酸血症均呈正相关。结果表明，慢性通气衰竭患者的长期氧疗（LTO2）对通过EEG测量的脑功能有有益影响。
