胃癌中的腹腔游离癌细胞及其活力
Intraperitoneal free cancer cells and their viability in gastric cancer.
作者信息
Iitsuka Y, Kaneshima S, Tanida O, Takeuchi T, Koga S
出版信息
Cancer. 1979 Oct;44(4):1476-80. doi: 10.1002/1097-0142(197910)44:4<1476::aid-cncr2820440442>3.0.co;2-r.
Free cancer cells in the peritoneal cavity of 100 patients with gastric cancer were examined by means of Douglas lavage, and their viability was estimated by 3H-thymidine uptake with autoradiographical technic. Furthermore, the effect of mitomycin-C on the viability of free cancer cells in the peritoneal cavity was studied. The appearance of intraperitoneal free cancer cells was dependent on the degree of invasion of cancer to the gastric serosa; that is, free cancer cells were not found in cases without serosal invasion, but were found in 48% with serosal invasion. The viability of free cancer cells in the peritoneal cavity was relatively high, but could be suppressed remarkably by intraperitoneal administration of 10 mg of mitomycin-C.
通过Douglas灌洗法对100例胃癌患者腹膜腔中的游离癌细胞进行检查，并采用放射自显影技术通过³H-胸腺嘧啶核苷摄取来评估其活力。此外，研究了丝裂霉素-C对腹膜腔中游离癌细胞活力的影响。腹膜腔内游离癌细胞的出现取决于癌症对胃浆膜的侵犯程度；也就是说，在无浆膜侵犯的病例中未发现游离癌细胞，但在有浆膜侵犯的病例中有48%发现了游离癌细胞。腹膜腔中游离癌细胞的活力相对较高，但腹腔注射10mg丝裂霉素-C可显著抑制其活力。
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