Nelson R, Bratescu A, Teodorescu M
Cancer. 1979 Nov;44(5):1665-70. doi: 10.1002/1097-0142(197911)44:5<1665::aid-cncr2820440520>3.0.co;2-q.
In previous studies we showed that spontaneous bacterial adherence can be used to identify human lymphocyte subpopulations and to demonstrate variable binding patterns in chronic lymphocytic leukemia (CLL). In this study, 10 strains of bacteria of different genera and species were used in blood smears from 24 CLL patients to determine the percentages of lymphocytes that bind bacteria. From these percentages, binding indices were calculated. The symptoms and other laboratory tests were independently recorded and the stages determined. When the two sets of data were compared, relatively low binding indices were found in symptomatic patients or in Stages III and IV; relatively high binding indices were found in asymptomatic patients or in Stages I and II. We suggest that with progression of leukemia, lymphocytes with less "lectin" recognition potential are selected and escape any control mechanism of proliferation.
在先前的研究中，我们表明，自发细菌黏附可用于识别人类淋巴细胞亚群，并证明慢性淋巴细胞白血病（CLL）中存在可变的结合模式。在本研究中，使用10株不同属和种的细菌对24例CLL患者的血涂片进行检测，以确定结合细菌的淋巴细胞百分比。根据这些百分比计算结合指数。独立记录症状和其他实验室检查结果并确定分期。当比较两组数据时，发现有症状的患者或Ⅲ期和Ⅳ期患者的结合指数相对较低；无症状患者或Ⅰ期和Ⅱ期患者的结合指数相对较高。我们认为，随着白血病的进展，具有较低“凝集素”识别潜能的淋巴细胞被选择出来，并逃脱了任何增殖控制机制。
