Davis S
N Engl J Med. 1976 May 20;294(21):1150-3. doi: 10.1056/NEJM197605202942104.
The percentages of T and B lymphocytes in 13 patients with chronic lymphocytic leukemia were determined at two-week intervals. One patient with "B-cell predominant" disease showed a decrease from 77 to 49 in the percentage of circulating B cells, which bind heat aggregated immunoglobulin and anti-human immunoglobulin. This patient had a comparable increase in T cells, which form rosettes with sheep erythrocytes. The lymphocytes of three other patients, who originally had equal percentages of cells that bound heat-aggregated immunoglobulin and anti-human immunoglobulin, lost lg determinants from 47 to 63 per cent of cells without changing the proportion of cells with receptors for heat-aggregated immunoglobulin or for sheep erythrocytes. The characterization of lymphocytes in chronic lymphocytic leukemia should include sequential determination of cell-surface markers for both T and B cells, since the disease does not represent a proliferation of B cells alone.
对13例慢性淋巴细胞白血病患者的T淋巴细胞和B淋巴细胞百分比每隔两周进行一次测定。1例“B细胞为主型”疾病患者循环中与热聚集免疫球蛋白和抗人免疫球蛋白结合的B细胞百分比从77%降至49%。该患者形成绵羊红细胞玫瑰花结的T细胞有相应增加。另外3例患者最初结合热聚集免疫球蛋白和抗人免疫球蛋白的细胞百分比相同，其淋巴细胞有47%至63%的细胞失去了lg决定簇，而结合热聚集免疫球蛋白或绵羊红细胞受体的细胞比例未变。慢性淋巴细胞白血病淋巴细胞的特征应包括对T细胞和B细胞的细胞表面标志物进行连续测定，因为该疾病并非仅表现为B细胞的增殖。
