转移性癌症对血小板单胺氧化酶活性和5-羟色胺代谢的影响。

Effect of metastatic cancer on platelet monoamine oxidase activity and serotonin metabolism.

作者信息

Feldman J M

出版信息

Cancer. 1979 Nov;44(5):1751-6. doi: 10.1002/1097-0142(197911)44:5<1751::aid-cncr2820440532>3.0.co;2-t.

DOI:10.1002/1097-0142(197911)44:5<1751::aid-cncr2820440532>3.0.co;2-t

Abstract

Platelet monoamine oxidase (MAO) activity and urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), serotonin, tyramine and tryptamine were measured in patients with a variety of metastatic cancers and in healthy control subjects. The patients with cancer had higher platelet MAO activity and lower urinary excretion of 5-HIAA, sertonin and tyramine than the healthy subjects. The urinary tryptamine excretion was not significantly different in the two groups. At the present time it is unclear if the alterations in platelet MAO activity and monoamine excretion are casually related.

摘要

在患有各种转移性癌症的患者和健康对照受试者中，测量了血小板单胺氧化酶（MAO）活性以及5-羟吲哚乙酸（5-HIAA）、血清素、酪胺和色胺的尿排泄量。癌症患者的血小板MAO活性较高，5-HIAA、血清素和酪胺的尿排泄量低于健康受试者。两组的尿色胺排泄量无显著差异。目前尚不清楚血小板MAO活性和单胺排泄的改变是否存在因果关系。