Model P, Webster R E, Zinder N D
Cell. 1979 Oct;18(2):235-46. doi: 10.1016/0092-8674(79)90043-6.
We have isolated a conditional lethal mutant of bacteriophage 12 which makes plaques only on E. coli strains carrying a UGA suppressor. It grows normally in nonsuppressing hosts but does not lyse such strains. The mutation complements with amber mutations in each of the three known phage cistrons. These observations lead us to postulate the existence of a fourth gene in the RNA phage.
我们分离出了噬菌体12的一个条件致死突变体，该突变体仅在携带UGA抑制基因的大肠杆菌菌株上形成噬菌斑。它在非抑制宿主中正常生长，但不会裂解这些菌株。该突变与三个已知噬菌体顺反子中的每一个中的琥珀突变互补。这些观察结果使我们推测RNA噬菌体中存在第四个基因。
