噬菌体：是时候重新评估噬菌体疗法作为一种有前途的控制多药耐药菌的药物的潜力了。
Bacteriophage: time to re-evaluate the potential of phage therapy as a promising agent to control multidrug-resistant bacteria.
机构信息
Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Iran J Basic Med Sci. 2012 Mar;15(2):693-701.
Abstract
Nowadays the most difficult problem in treatment of bacterial infections is the appearance of resistant bacteria to the antimicrobial agents so that the attention is being drawn to other potential targets. In view of the positive findings of phage therapy, many advantages have been mentioned which utilizes phage therapy over chemotherapy and it seems to be a promising agent to replace the antibiotics. This review focuses on an understanding of phages for the treatment of bacterial infectious diseases as a new alternative treatment of infections caused by multiple antibiotic resistant bacteria. Therefore, utilizing bacteriophage may be accounted as an alternative therapy. It is appropriate time to re-evaluate the potential of phage therapy as an effective bactericidal and a promising agent to control multidrug-resistant bacteria.
摘要
如今，在治疗细菌感染方面，最困难的问题是出现了对抗生素具有耐药性的细菌，因此人们开始关注其他潜在的目标。鉴于噬菌体治疗的积极发现，已经提到了许多利用噬菌体治疗优于化学治疗的优势，并且噬菌体似乎是一种有前途的抗生素替代品。本文综述了噬菌体作为治疗细菌感染性疾病的新方法，以替代治疗多种抗生素耐药菌引起的感染。因此，利用噬菌体可能是一种替代疗法。现在是重新评估噬菌体治疗作为一种有效杀菌剂和控制多药耐药菌的有前途的药物的潜力的合适时机。
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