Baur X
Clin Allergy. 1979 Sep;9(5):451-7. doi: 10.1111/j.1365-2222.1979.tb02508.x.
The sera of seven patients clinically hypersensitive to papain--in one case also to baromelain--and the sera of sixty asthmatic patients with allergies to other inhalant and food allergens were investigated for IgE antibody activity to the plant proteases papain and bromelain and to common allergens by RAST, confirmed in some sera by RAST inhibition. There seems to be a relation between the antibody reactions to papain and bromelain, in several cases also between the reactions to these proteases and to grass pollen and flour. Studies by RAST inhibition showed that papain, bromelain, wheat flour, rye flour, grass pollen and birch pollen mutually inhibit IgE antibody to each antigen; but the degree of inhibition varies among the different sera and allergens. Our results suggest that these allergens from various plants, besides having specific antigenic determinants, also possess similar or even identical antigenically active regions, leading to immunological cross-reactivity.
对七名临床上对木瓜蛋白酶过敏（其中一例还对菠萝蛋白酶过敏）的患者血清，以及六十名对其他吸入性和食物过敏原过敏的哮喘患者血清，通过放射变应原吸附试验（RAST）检测其针对植物蛋白酶木瓜蛋白酶和菠萝蛋白酶以及常见过敏原的IgE抗体活性，部分血清通过RAST抑制试验进行确认。木瓜蛋白酶和菠萝蛋白酶的抗体反应之间似乎存在关联，在一些情况下，这些蛋白酶与草花粉和面粉的反应之间也存在关联。RAST抑制试验研究表明，木瓜蛋白酶、菠萝蛋白酶、小麦粉、黑麦粉、草花粉和桦树花粉相互抑制针对每种抗原的IgE抗体；但不同血清和过敏原之间的抑制程度有所不同。我们的结果表明，这些来自不同植物的过敏原，除了具有特定的抗原决定簇外，还拥有相似甚至相同的抗原活性区域，从而导致免疫交叉反应。
