尿毒症血清中脂肪族二羧酸的模式，包括一种新的有机酸，2,4-二甲基己二酸。

Pattern of aliphatic dicarboxylic acids in uremic serum including a new organic acid, 2,4-dimethyladipic acid.

作者信息

Niwa T, Ohki T, Maeda K, Saito A, Kobayashi K

出版信息

Clin Chim Acta. 1979 Nov 15;99(1):71-83. doi: 10.1016/0009-8981(79)90141-4.

Abstract

(1) 2,4-Dimethyladipic acid was first identified in normal human urine using gas chromatography-mass spectrometry. Urinary excretion of 2,4-dimethyladipic acid in 7 healthy adults ranged from 4.9 mumol to 14 mumol per 24 h. (2) Succinic acid, adipic acid, 3-methyladipic acid, 2,4-dimethyladipic acid, pimelic acid and azelaic acid were identified in the ultrafiltrate of the blood obtained from a chronic uremic patient using a hemodialyzer. (3) Levels of succinic acid, adipic acid, 3-methyladipic acid, 2,4-dimethyladipic acid, pimelic acid and azelaic acid in uremic serum were determined using a mass fragmentographic technique. Concentration of succinic acid in uremic serum was comparable to that in normal serum, whereas concentrations of adipic acid, 3-methyladipic acid, 2,4-dimethyladipic acid, pimelic acid and azelaic acid were highly elevated in uremic serum.

摘要

(1) 2,4-二甲基己二酸首先通过气相色谱-质谱联用技术在正常人尿液中被鉴定出来。7名健康成年人24小时尿液中2,4-二甲基己二酸的排泄量在4.9微摩尔至14微摩尔之间。(2) 使用血液透析器从一名慢性尿毒症患者获取的血液超滤液中鉴定出了琥珀酸、己二酸、3-甲基己二酸、2,4-二甲基己二酸、庚二酸和壬二酸。(3) 采用质量碎片色谱技术测定了尿毒症血清中琥珀酸、己二酸、3-甲基己二酸、2,4-二甲基己二酸、庚二酸和壬二酸的水平。尿毒症血清中琥珀酸的浓度与正常血清中的相当，而己二酸、3-甲基己二酸、2,4-二甲基己二酸、庚二酸和壬二酸的浓度在尿毒症血清中显著升高。