van Waes P F
Diagn Imaging. 1979;48(4):209-15.
Metrizamide (Amipaque) and ioxaglate (Hexabrix), both new low osmolality contrast agents, were evaluated in a comparative study of 50 patients with peripheral arterial diseases undergoing in total 118 angiograms. The degree of discomfort caused by the highly selective injection of these compounds and the normal available water-soluble media was estimated. Metrizamide resulted as the optimal contrast medium and Hexabrix is second best. Intra-arterial lidocaine reduced serious discomfort from 70 to 15% in conventional media. None of the evaluated contrast compounds was changing blood flow in this group of patients. But pharmacoangiography with high dosages of tolazoline could provide additional information on vascular pathophysiology.
甲泛葡胺（阿米培克）和碘克沙醇（六溴化合物）均为新型低渗造影剂，在一项对50例外周动脉疾病患者进行的比较研究中进行了评估，这些患者共接受了118次血管造影。评估了这些化合物的高选择性注射以及常规可用水溶性介质所引起的不适程度。结果表明甲泛葡胺是最佳造影剂，碘克沙醇次之。动脉内注射利多卡因可使传统介质引起的严重不适从70%降至15%。在所评估的造影剂中，没有一种会改变该组患者的血流。但高剂量妥拉唑啉的药物血管造影可提供有关血管病理生理学的额外信息。
