Greenwood B M, Herrick E M, Holborow E J
Clin Exp Immunol. 1970 Jul;7(1):75-83.
Speckled antinuclear factor reacting with rat liver nuclei was found in a high proportion of sera from apparently healthy inhabitants of Western Nigeria, Northern Nigeria, Liberia and Uganda. A significant relationship was found between the occurrence of the antibody in Nigerian sera and the presence of high levels of malaria antibody and of high levels of IgM. Speckled antinuclear factor was also found in the sera of CBA mice infected with . These findings suggest that the speckled antinuclear factor found in African sera may be a cross-reacting antibody to a nuclear component of malaria parasites. The demonstration of speckled antinuclear factor in the serum of a subject who has been resident in part of tropical Africa cannot be taken as a reliable indication of the presence of a connective tissue disease.
在来自尼日利亚西部、尼日利亚北部、利比里亚和乌干达的看似健康的居民的大部分血清中，发现了与大鼠肝细胞核发生反应的斑点状抗核因子。在尼日利亚血清中该抗体的出现与高水平疟疾抗体和高水平IgM的存在之间发现了显著关联。在感染了 的CBA小鼠血清中也发现了斑点状抗核因子。这些发现表明，在非洲血清中发现的斑点状抗核因子可能是针对疟原虫核成分的交叉反应抗体。对于曾居住在热带非洲部分地区的受试者，其血清中斑点状抗核因子的检测结果不能作为结缔组织病存在的可靠指标。
