Greenwood B M
Clin Exp Immunol. 1970 Feb;6(2):197-206.
A heterophile agglutinin was found at a titre of 1:4 or greater in 332 of 336 Nigerian sera investigated. The antibody was demonstrated to be an IgM macroglobulin. Although many of the sera tested had high IgM levels, only a slight correlation was found between titres of heterophile agglutinin and IgM levels. Absorption studies differentiated the Nigerian heterophile agglutinin from the antibodies seen in glandular fever and serum sickness. No correlation was found between the occurrence of high titres of heterophile agglutinin and infection with malaria, onchocerciasis, loaisis or schistosomiasis. None of the subjects investigated was known to have trypanosomiasis, a parasitic infection in which heterophile antibodies are known to occur.
在检测的336份尼日利亚血清中，有332份的嗜异性凝集素效价达到或高于1:4。该抗体被证实为IgM巨球蛋白。尽管许多检测的血清IgM水平较高，但嗜异性凝集素效价与IgM水平之间仅发现轻微相关性。吸收研究将尼日利亚嗜异性凝集素与传染性单核细胞增多症和血清病中所见的抗体区分开来。未发现高滴度嗜异性凝集素的出现与疟疾、盘尾丝虫病、罗阿丝虫病或血吸虫病感染之间存在相关性。所调查的受试者均无人患锥虫病，锥虫病是一种已知会出现嗜异性抗体的寄生虫感染。
