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放射性碘化酪氨酸衍生物在肾上腺髓质和黑色素瘤中的蓄积。

Accumulation of radioiodinated tyrosine derivatives in the adrenal medulla and in melanomas.

作者信息

Kloss G, Leven M

出版信息

Eur J Nucl Med. 1979 Jun 1;4(3):179-86. doi: 10.1007/BF00620482.

DOI:10.1007/BF00620482
PMID:499239
Abstract

Because tyrosine and dopa can be regarded as precursors of adrenomedullary hormones and melanin, radioiodinated derivatives of these compounds were tested for their accumulation in the adrenal medulla and in melanomas of various animal species. The highest level of accumulation in the adrenal medulla was attained in mice and rats with iodinated beta-hydroxy-alpha-methyltyramine, and in melanomas of mice with iodinated alpha-methyltyrosine. The results could not be reproduced to the same extent in other species.

摘要

由于酪氨酸和多巴可被视为肾上腺髓质激素和黑色素的前体，因此对这些化合物的放射性碘化衍生物在各种动物物种的肾上腺髓质和黑色素瘤中的蓄积情况进行了测试。在小鼠和大鼠中，碘化β-羟基-α-甲基酪胺在肾上腺髓质中的蓄积水平最高；在小鼠的黑色素瘤中，碘化α-甲基酪氨酸的蓄积水平最高。在其他物种中，无法在相同程度上重现这些结果。

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本文引用的文献

1
THE INCORPORATION OF C14 FROM 3,4-DIHYDROXYPHENYLALANINE-2'-C14 INTO THE MELANIN OF MOUSE MELANOMAS.3,4-二羟基苯丙氨酸-2'-C¹⁴中的C¹⁴掺入小鼠黑色素瘤黑色素的过程。
Cancer Res. 1964 Jun;24:863-8.
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[EFFECT OF THE DOPA-DECARBOXYLASE INHIBITOR ALPHA-METHYLDOPA ON THE INCORPORATION OF DOPA INTO MELANIN AND PYROCATECHOLAMINE. IN VIVO STUDIES ON MELANOMA MICE WITH TRITIATED DOPA].[多巴脱羧酶抑制剂α-甲基多巴对多巴掺入黑色素和儿茶酚胺的影响。用氚标记多巴对黑色素瘤小鼠进行的体内研究]
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N-(2-diethylaminoethyl)-4-[123I]iodobenzamide as a tracer for the detection of malignant melanoma: simple synthesis, improved labelling technique and first clinical results.N-(2-二乙氨基乙基)-4-[123I]碘苯甲酰胺作为检测恶性黑色素瘤的示踪剂：简便合成、改进的标记技术及初步临床结果
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5
Canine SPECT studies for cerebral amino acid transport by means of 123I-3-iodo-alpha-methyl-L-tyrosine and preliminary kinetic analysis.利用123I-3-碘-α-甲基-L-酪氨酸进行犬脑氨基酸转运的单光子发射计算机断层扫描（SPECT）研究及初步动力学分析。
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Noncontact detection of ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine: first clinical results.
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Noncontact detection of experimental amelanotic ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine.用L-3-123I-碘-α-甲基酪氨酸对实验性无色素性眼黑色素瘤进行非接触检测。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;217(4):255-66. doi: 10.1007/BF00429286.
8
Melanoma affine radiopharmaceuticals I. A comparative study of 131I-labeled quinoline and tyrosine derivatives.黑色素瘤亲和放射性药物I. 131I标记喹啉和酪氨酸衍生物的比较研究
Eur J Nucl Med. 1981;6(5):227-33. doi: 10.1007/BF00290568.
9
[125I] radioiodinated metaraminol: a new platelet-specific labeling agent.[125I]放射性碘化间羟胺：一种新型血小板特异性标记剂。
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Tracers for metabolic imaging of brain and heart. Radiochemistry and radiopharmacology.用于脑和心脏代谢成像的示踪剂。放射化学与放射药理学。
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[关于黑色素瘤的可控放射治疗以及在给予 H-3 标记的多巴后通过选择性 H-3 掺入对嗜铬系统的研究]
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[Animal whole-body autoradiography, a method of drug research].[动物全身放射自显影术，一种药物研究方法]
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J Invest Dermatol. 1968 Mar;50(3):250-3.