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用L-3-123I-碘-α-甲基酪氨酸对实验性无色素性眼黑色素瘤进行非接触检测。

Noncontact detection of experimental amelanotic ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine.

作者信息

Bockslaff H, Spitznas M, Hahn I, Kloster G

出版信息

Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;217(4):255-66. doi: 10.1007/BF00429286.

DOI:10.1007/BF00429286
PMID:6915722
Abstract

An application of L-3-123I-iodo-alpha-methyltyrosine for the detection of ocular melanoma is presented. In rabbits with malignant Greene amelanotic melanoma transplanted to the anterior chamber of the eye, all tumors were detected in positive contrast using a gamma camera with a single pinhole collimator. The smallest tumor identified weighed 65 mg. Our data are compared with those obtained with 32PO4, 67Ga, 203Pb or labelled iodochloroquine.

摘要

介绍了L-3-123I-碘-α-甲基酪氨酸在检测眼黑色素瘤中的应用。在将恶性格林无色素性黑色素瘤移植到眼前房的兔子中，使用带有单针孔准直器的γ相机以阳性对比检测到所有肿瘤。鉴定出的最小肿瘤重65毫克。我们的数据与用32PO4、67Ga、203Pb或标记的碘氯喹啉获得的数据进行了比较。

相似文献

1
Noncontact detection of experimental amelanotic ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine.用L-3-123I-碘-α-甲基酪氨酸对实验性无色素性眼黑色素瘤进行非接触检测。
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1981;217(4):255-66. doi: 10.1007/BF00429286.
2
Noncontact detection of ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine: first clinical results.
Graefes Arch Clin Exp Ophthalmol. 1982;219(3):149-54. doi: 10.1007/BF02152302.
3
L-3-123I-alpha-methyltyrosine for melanoma detection: a comparative evaluation.用于黑色素瘤检测的L-3-123I-α-甲基酪氨酸：一项比较评估
Int J Nucl Med Biol. 1982;9(4):259-69. doi: 10.1016/0047-0740(82)90086-9.
4
Uptake of 123I-5-iodo-2-thiouracil, a possible radiopharmaceutical for noninvasive detection of ocular melanoma, in melanotic and amelanotic melanomas in hamsters.123I-5-碘-2-硫脲嘧啶（一种可能用于无创检测眼黑色素瘤的放射性药物）在仓鼠黑色素瘤和无黑色素黑色素瘤中的摄取情况。
Nucl Med Commun. 1985 Oct;6(10):657-63. doi: 10.1097/00006231-198510000-00007.
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Potential radiopharmaceuticals for the detection of ocular melanoma. Part I. 5-iodo-2-thiouracil derivatives.用于检测眼部黑色素瘤的潜在放射性药物。第一部分。5-碘-2-硫脲衍生物。
Eur J Nucl Med. 1983;8(2):45-51. doi: 10.1007/BF00252555.
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Scintimetric detection of choroidal malignant melanoma with [123I]-5-iodo-2-thiouracil.
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[Noncontact detection of intraocular lesions by means of a gamma scintillation camera].[利用γ闪烁照相机对眼内病变进行非接触式检测]
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1979 Sep;211(3):187-203. doi: 10.1007/BF02387424.
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Detection of ocular melanoma with 4-(3-dimethylaminopropylamino)-7-[123I]-iodoquinoline.
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Potential radiopharmaceuticals for the detection of ocular melanoma. Part II. Iodoquinoline derivatives and 67Ga-citrate.用于检测眼黑色素瘤的潜在放射性药物。第二部分。碘喹啉衍生物和枸橼酸镓。
Eur J Nucl Med. 1986;12(2):96-104. doi: 10.1007/BF00364737.
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Melanoma affine radiopharmaceuticals I. A comparative study of 131I-labeled quinoline and tyrosine derivatives.黑色素瘤亲和放射性药物I. 131I标记喹啉和酪氨酸衍生物的比较研究
Eur J Nucl Med. 1981;6(5):227-33. doi: 10.1007/BF00290568.

引用本文的文献

1
Noncontact detection of ocular melanoma with L-3-123I-iodo-alpha-methyltyrosine: first clinical results.
Graefes Arch Clin Exp Ophthalmol. 1982;219(3):149-54. doi: 10.1007/BF02152302.
2
Radiation doses to the eye lens from ocular tumour seeking radiopharmaceuticals.用于眼部肿瘤诊断的放射性药物对晶状体的辐射剂量。
Eur J Nucl Med. 1983;8(3):127-30. doi: 10.1007/BF00256737.
3
Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in a patient with advanced malignant melanoma.
Eur J Nucl Med. 1986;12(7):353-6. doi: 10.1007/BF00263819.

本文引用的文献

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Fundamental limitations of radiophosphorus counting methods used for detection of intraocular neoplasm.用于检测眼内肿瘤的放射性磷计数方法的基本局限性。
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2
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Subchoroidal transplantation of experimental malignant melanoma.
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Gallium-67 scintigraphy in malignant melanoma.恶性黑色素瘤的镓-67闪烁扫描术
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Biomedicine. 1973 Mar 20;19(3):122-5.
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Accumulation of drugs on melanin.
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Quinoline analog labeled with iodine 123 in melanoma detection.用于黑色素瘤检测的碘123标记的喹啉类似物。
Arch Ophthalmol. 1975 Jul;93(7):504-8. doi: 10.1001/archopht.1975.01010020520007.
10
Localization of radioactive lead in ocular and skin melanoma.放射性铅在眼部和皮肤黑色素瘤中的定位
Invest Ophthalmol. 1975 Jun;14(6):492-4.