Swenerton H, Hurley L S
Science. 1971 Jul 2;173(3991):62-4. doi: 10.1126/science.173.3991.62.
Ingestion of a chelating agent (ethylenediaminetetraacetic acid) by female rats during pregnancy impaired reproduction and resulted in congenitally malformed young. When ethylenediaminetetraacetic acid was fed from days 6 to 21 of gestation, all of the full-term young had gross congenital malformations. These effects were prevented by simultaneous supplementation with 1000 parts per million of dietary zinc.
怀孕母鼠在孕期摄入螯合剂（乙二胺四乙酸）会损害生殖功能，并导致幼崽先天性畸形。在妊娠第6天至第21天喂食乙二胺四乙酸时，所有足月幼崽都出现了明显的先天性畸形。同时在饮食中补充百万分之一千的锌可防止这些影响。
