Källén B, Löw B, Nilsson O
Acta Neurol Scand. 1975 Mar;51(3):184-92. doi: 10.1111/j.1600-0404.1975.tb07599.x.
Compared with the mixed leukocyte reaction (MLR) between cells from healthy individuals, the MLR between cells from two patients with multiple sclerosis (MS) is, on average, reduced in strength. There is a tendency for the most marked reduction of MLR to occur when both or neither of the members in a tested pair carry HL-A7, and when cells from patients in a relatively early stage of the disease (short duration, relapses but no permanent disablement) are studied; especially when cells from these patients are used as reactor clels in the MLR. Repeated studies of the same cell combinations with varying intervals showed that when both members of the pair carry HL-A7,--and therefore have a large chance also to carry LD-7a--the MLR strength is relatively constant. When only one or neither of the members carry HL-A7, the strength of MLR varies considerably. Probably two different mechanisms exist in MLR impairment: similarity of LD genes, and "immunosuppressive" factors which can vary during the course of the disease.
与健康个体细胞之间的混合淋巴细胞反应（MLR）相比，两名多发性硬化症（MS）患者细胞之间的MLR强度平均降低。当测试对中的两个成员都携带或都不携带HL - A7时，以及当研究疾病相对早期阶段（病程短、有复发但无永久性残疾）患者的细胞时，尤其是当这些患者的细胞用作MLR中的反应细胞时，MLR最明显降低的趋势会出现。对相同细胞组合进行不同间隔的重复研究表明，当对中的两个成员都携带HL - A7时（因此也有很大机会携带LD - 7a），MLR强度相对恒定。当只有一个成员或两个成员都不携带HL - A7时，MLR强度变化很大。MLR损伤可能存在两种不同机制：LD基因的相似性，以及在疾病过程中可能变化的“免疫抑制”因子。
