Weksler B B, Nachman R L
J Exp Med. 1971 Nov 1;134(5):1114-30. doi: 10.1084/jem.134.5.1114.
The heat-stable antibacterial activity of rabbit serum against Gram-positive microorganisms has been shown to reside in a cationic protein fraction of platelet lysosomal granules. The activity is released during platelet aggregation. No plasma or serum component is required for the bactericidal effect. The platelet bactericidin resembles the antibacterial proteins of leukocyte granules both in cellular localization and in biochemical characteristics. It can be differentiated from platelet factor 4, the antiheparin factor, which is also a basic protein in platelet granules. The antibacterial effect of the platelet bactericidin may be related to the metabolic activity of the organisms. This antibacterial activity of platelets may represent another means by which platelets can participate in host inflammatory defense reactions.
兔血清对革兰氏阳性微生物的热稳定抗菌活性已被证明存在于血小板溶酶体颗粒的阳离子蛋白部分。该活性在血小板聚集过程中释放。杀菌作用不需要血浆或血清成分。血小板杀菌素在细胞定位和生化特性方面都类似于白细胞颗粒的抗菌蛋白。它可以与血小板因子4（抗肝素因子）区分开来，血小板因子4也是血小板颗粒中的一种碱性蛋白。血小板杀菌素的抗菌作用可能与微生物的代谢活性有关。血小板的这种抗菌活性可能代表了血小板参与宿主炎症防御反应的另一种方式。
