血清中血小板依赖性趋化活性的产生
Platelet-dependent generation of chemotactic activity in serum.
作者信息
Weksler B B, Coupal C E
出版信息
J Exp Med. 1973 Jun 1;137(6):1419-30. doi: 10.1084/jem.137.6.1419.
Abstract
A protein fraction extracted from the lysosomal granules of human platelets generated chemotactic activity for polymorphonuclear leukocytes when incubated with fresh serum. The platelet factor was also released during platelet aggregation with collagen or epinephrine and appeared to be released during blood clotting. Heated serum did not support the platelet-dependent generation of chemotactic activity. Treatment of fresh serum with antibody to the fifth component of complement also prevented development of activity. Purified human C5 but not C3 yielded chemotactic activity upon incubation with the platelet factor. Thus, human platelets are capable of stimulating chemotaxis via complement activation in a manner similar to leukocytes, and may therefore participate in the early stages of inflammation.
摘要
从人血小板溶酶体颗粒中提取的一种蛋白质组分，与新鲜血清一起孵育时，可产生对多形核白细胞的趋化活性。血小板因子在血小板与胶原蛋白或肾上腺素聚集过程中也会释放，并且在血液凝固过程中似乎也会释放。加热的血清不支持依赖血小板产生趋化活性。用针对补体第五成分的抗体处理新鲜血清也可阻止活性的产生。纯化的人C5而非C3与血小板因子一起孵育时可产生趋化活性。因此，人血小板能够通过补体激活以类似于白细胞的方式刺激趋化作用，因此可能参与炎症的早期阶段。
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