Laltoo H, Kind L S
Infect Immun. 1979 Oct;26(1):30-5. doi: 10.1128/iai.26.1.30-35.1979.
Oxazolone-sensitized mite-infested (SWR-M) and mite-free (SWR-J) mice were challenged with oxazolone on the skin of the neck and shoulder. The migration of radioactively labeled cells to the site of contact sensitivity reaction to oxazolone was significantly less in SWR-M than in SWR-J mice. Serum obtained from SWR-M mice suppressed the extravasation of cells into the skin site of SWR-J mice challenged with oxazolone. The decrease in cellular influx in SWR-M mice occurred in areas of mite infestation (skin of neck and shoulder) as well as in areas not infested with mites (the ears). SWR-M mice also gave evidence of enhanced vascular permeability. A possible role for histamine in the inhibition of contact sensitivity in mite-infested mice is discussed.
用恶唑酮致敏的有螨（SWR-M）和无螨（SWR-J）小鼠，在其颈部和肩部皮肤用恶唑酮进行激发。放射性标记细胞向恶唑酮接触性敏感反应部位的迁移，在SWR-M小鼠中显著少于SWR-J小鼠。从SWR-M小鼠获得的血清抑制了用恶唑酮激发的SWR-J小鼠皮肤部位细胞的渗出。SWR-M小鼠细胞内流的减少发生在有螨感染的区域（颈部和肩部皮肤）以及未感染螨虫的区域（耳朵）。SWR-M小鼠还表现出血管通透性增强。讨论了组胺在有螨感染小鼠接触性敏感抑制中的可能作用。
