神经氨酸酶与对甲型流感病毒香港A2活疫苗接种的抗性
Neuraminidase and resistance to vaccination with live influenza A2 Hong Kong vaccines.
作者信息
Slepushkin A N, Schild G C, Beare A S, Chinn S, Tyrrell D A
出版信息
J Hyg (Lond). 1971 Dec;69(4):571-8. doi: 10.1017/s0022172400021847.
Abstract
Thirty-seven volunteers were inoculated intranasally with living attenuated influenza A2 viruses. Rising titres of circulating antineuraminidase (AN) were detected in 14 of 17 infected volunteers. AN was also found in nasal secretions. Statistical analysis showed that there was a correlation between the titres of haemagglutination-inhibiting antibody (HI) and AN in nasal washings, and between AN in blood and washings. Resistance to infection could be predicted from antibody titres in 29 of 37 volunteers and blood AN alone predicted the outcome of 25 volunteers.
摘要
37名志愿者经鼻内接种了减毒活甲型流感病毒A2。在17名受感染志愿者中的14名检测到循环抗神经氨酸酶（AN）滴度升高。在鼻分泌物中也发现了AN。统计分析表明，鼻洗液中血凝抑制抗体（HI）滴度与AN之间、血液和洗液中的AN之间存在相关性。37名志愿者中有29名可根据抗体滴度预测感染抵抗力，仅血液中的AN就能预测25名志愿者的结果。
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