Kisumi M, Kato J, Sugiura M, Chibata I
Appl Microbiol. 1971 Dec;22(6):987-91. doi: 10.1128/am.22.6.987-991.1971.
l-Arginine hydroxamate inhibited the growth of various bacteria, and the inhibition was readily reversed by arginine. l-Arginine hydroxamate (10(-3)m) completely inhibited the growth of Bacillus subtilis. This inhibitory effect was prevented by 2.5 x 10(-4)ml-arginine, which was the most effective of all the natural amino acids in reversing the inhibition. l-Arginine hydroxamate-resistant mutants of Bacillus subtilis were isolated and found to excrete l-arginine in relatively high yields. One of the mutants, strain AHr-5, produced 4.5 mg of l-arginine per ml in shaken culture in 3 days.
L-精氨酸异羟肟酸盐抑制多种细菌的生长,且这种抑制作用可被精氨酸轻易逆转。L-精氨酸异羟肟酸盐(10⁻³m)完全抑制枯草芽孢杆菌的生长。2.5×10⁻⁴m的L-精氨酸可阻止这种抑制作用,它是所有天然氨基酸中逆转抑制作用最有效的。分离出了枯草芽孢杆菌的L-精氨酸异羟肟酸盐抗性突变体,发现它们能以相对较高的产量分泌L-精氨酸。其中一个突变体AHr-5菌株,在摇瓶培养3天后,每毫升产生4.5毫克L-精氨酸。