Cumming G R, Borysyk L, Dufresne C
Can Med Assoc J. 1972 Mar 18;106(6):649-53.
Lead MC5 bipolar exercise ECG was obtained in 510 asymptomatic males, aged 40 to 65, utilizing the bicycle ergometer, with maximal stress in 71% of the subjects. "Ischemic changes" occurred in 61 subjects, the frequency increasing from 4% at age 40 to 45, to 20% at age 50 to 55, to 37% at age 61 to 65. Subjects having an ischemic type ECG change on exercise had more frequent minor resting ECG changes, more resting hypertension, and a greater incidence of high cholesterol values than subjects with a normal ECG response to exercise, but there was no difference in the incidence of obesity, low fitness, or high systolic blood pressure after exercise. Current evidence suggests that asymptomatic male subjects with an abnormal exercise ECG develop clinical coronary heart disease from 2.5 to over 30 times more frequently than those with a normal exercise ECG.
对510名年龄在40至65岁的无症状男性进行了导联MC5双极运动心电图检查,使用自行车测力计,71%的受试者达到最大负荷。61名受试者出现了“缺血性改变”,其发生率从40至45岁时的4%,增至50至55岁时的20%,再到61至65岁时的37%。运动时心电图出现缺血型改变的受试者,与运动心电图反应正常的受试者相比,静息时心电图轻微改变更频繁,静息高血压更多,高胆固醇值发生率更高,但肥胖、身体适应性差或运动后收缩压高的发生率没有差异。目前的证据表明,运动心电图异常的无症状男性受试者发生临床冠心病的频率比运动心电图正常的受试者高2.5至30倍以上。