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肺炎球菌性脑膜炎患者脑脊液中的纤维蛋白降解产物

Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal meningitis.

作者信息

Cleland P G, Macfarlane J T, Baird D R, Greenwood B M

出版信息

J Neurol Neurosurg Psychiatry. 1979 Sep;42(9):843-6. doi: 10.1136/jnnp.42.9.843.

Abstract

Raised levels of fibrin degradation products were found in the cerebrospinal fluid of nearly all of 35 patients with pneumococcal meningitis. The mean level was higher in patients who died subsequently than in those who survived. Cerebrospinal fluid from patients with pneumococcal meningitis showed increased fibrinolytic activity as assessed by clot lysis, suggesting local production of fibrin degradation products within the subarachnoid space.

摘要

在35例肺炎球菌性脑膜炎患者中,几乎所有人的脑脊液中纤维蛋白降解产物水平都有所升高。随后死亡的患者其平均水平高于存活患者。通过凝块溶解评估发现,肺炎球菌性脑膜炎患者的脑脊液显示出纤溶活性增加,提示蛛网膜下腔内局部产生了纤维蛋白降解产物。

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Heat denaturation of plasminogen in the fibrin plate method.纤维蛋白平板法中纤溶酶原的热变性
Acta Physiol Scand. 1953 Feb 28;27(4):371-6. doi: 10.1111/j.1748-1716.1953.tb00951.x.
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Mortality from pneumococcal meningitis.
Lancet. 1976 Dec 18;2(7999):1344-6. doi: 10.1016/s0140-6736(76)91985-1.

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