5-羟色胺对豚鼠胃离体肌条的作用。
Effects of 5-hydroxytryptamine on isolated strips of the guinea-pig stomach.
作者信息
Yamaguchi T
出版信息
Br J Pharmacol. 1972 Jan;44(1):100-8. doi: 10.1111/j.1476-5381.1972.tb07242.x.
Abstract
- The effects of 5-hydroxytryptamine (5-HT) on isolated strips of the longitudinal and circular muscles of the guinea-pig stomach were investigated.2. 5-HT (0.1-1 mug/ml) increased the resting tension of the longitudinal muscle while it decreased that of the circular muscle. These effects were blocked by lysergic acid diethylamide (LSD), but were not affected by tetrodotoxin, hyoscine or morphine.3. Electrical stimulation caused contraction in the longitudinal muscle, and contraction followed by relaxation in the circular muscle. In both the longitudinal and circular muscles, the evoked contractions were potentiated by 5-HT. This effect was blocked by tetrodotoxin, hyoscine and morphine, but was not affected by LSD.4. It is concluded that, in the stomach as well as the intestine of the guinea-pig, there are two kinds of 5-HT receptors: the morphine-sensitive M receptor is situated on the intramural nerves and the D-receptor on the smooth muscle cells.
摘要
研究了5-羟色胺（5-HT）对豚鼠胃纵行肌和环行肌离体肌条的作用。
5-HT（0.1 - 1微克/毫升）可增加纵行肌的静息张力，同时降低环行肌的静息张力。这些作用可被麦角酸二乙胺（LSD）阻断，但不受河豚毒素、东莨菪碱或吗啡的影响。
电刺激可引起纵行肌收缩，环行肌则先收缩后舒张。在纵行肌和环行肌中，5-HT均可增强诱发的收缩。此作用可被河豚毒素、东莨菪碱和吗啡阻断，但不受LSD影响。
得出结论，在豚鼠的胃和肠道中，存在两种5-HT受体：吗啡敏感的M受体位于壁内神经上，D受体位于平滑肌细胞上。
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本文引用的文献
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2
The inhibitory action of morphine on the contraction of the longitudinal muscle coat of the isolated guinea-pig ileum.吗啡对离体豚鼠回肠纵行肌层收缩的抑制作用。
Br J Pharmacol Chemother. 1958 Sep;13(3):296-303. doi: 10.1111/j.1476-5381.1958.tb00906.x.
3
A sensitive method for the assay of 5-hydroxytryptamine.一种测定5-羟色胺的灵敏方法。
Br J Pharmacol Chemother. 1957 Sep;12(3):344-9. doi: 10.1111/j.1476-5381.1957.tb00146.x.
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Two kinds of tryptamine receptor.两种色胺受体。
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