Estimating the number of organisms in quantal assays.
作者信息
Wyshak G, Detre K
出版信息
Appl Microbiol. 1972 Apr;23(4):784-90. doi: 10.1128/am.23.4.784-790.1972.
Abstract
It has been demonstrated by virologists that, when procedural difficulties can be overcome and host variation can be eliminated, dosage-response data from virus assays conform with the one-particle theory of infection for both plaque counts and tissue cultures. Based on this theory, the number of virus particles from quantal virus assays can be estimated. Here a set of tables is presented from which the number of estimated particles can be obtained directly for several dilution factors and a number of dilution levels. Maximum likelihood estimation of particle counts is also illustrated using a computer program that we have prepared.
摘要
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