巴特综合征的药理学研究：抗利尿药和抗前列腺素药物治疗的相反作用。第一部分。
Pharmacologic studies in Bartter's syndrome: opposite effects of treatment with antikaliuretic and antiprostaglandin drugs. Part I.
作者信息
Simatupang T A, Radó J P, Boer P, Geyskes G G, Vos J, Dorhout Mees E J
出版信息
Int J Clin Pharmacol Biopharm. 1978 Jan;16(1):14-8.
The effect of antikaliuretic agents (spironolactone, amiloride) and antiprostaglandin agents (indomethacin, ibuprofen) on plasma renin activity and potassium metabolism was studied in a patient with familial Bartter's syndrome. The decrease in renal potassium clearance in response to antikaliuretic treatment was only of a temporary nature, in contrast to the marked potassium retention seen after indomethacin therapy. Plasma renin activity showed a consistent increase after kaliuretics and a marked decrease in response to antiprostaglandin agents. The opposite effect of the drugs on plasma renin activity, due to their different sites of action on the pathophysiologic chain of events in Bartter's syndrome, given an explanation for the contrasting therapeutic results.
在一名患有家族性巴特综合征的患者中，研究了抗利尿药物（螺内酯、氨氯吡脒）和抗前列腺素药物（吲哚美辛、布洛芬）对血浆肾素活性和钾代谢的影响。与吲哚美辛治疗后明显的钾潴留相反，抗利尿治疗引起的肾钾清除率降低只是暂时的。利尿剂治疗后血浆肾素活性持续升高，而抗前列腺素药物治疗后则显著降低。由于这些药物在巴特综合征病理生理事件链上的作用部位不同，它们对血浆肾素活性产生相反的影响，这就解释了治疗结果的差异。
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