Halie M R, Seldenrath J J, Stam H C, Nieweg H O
Br Med J. 1972 Jun 10;2(5814):611-3. doi: 10.1136/bmj.2.5814.611.
Studies of peripheral blood leucocyte concentrates in patients with Hodgkin's disease showed two types of cells believed to be typical for the disease in a number of patients. Involvement of the spleen as diagnosed after splenectomy and histological examination showed a close correlation with the presence of these characteristic cells in the peripheral blood. This is believed to be an argument for haematogenous spread or a multicentric origin of the disease in these cases. The results of attempted curative high-voltage radiotherapy with total node irradiation in 24 patients seem to support this concept. On the basis of the Rye classification of clinical stages the results of radiotherapy are not predictable. Six patients in stage II and seven in stage III were in remission, one in each of stages II and IV, and six in stage III had recurrences of the disease within one year. A division into localized or disseminated forms of the disease based on the investigations of blood and spleen showed all localized cases in remission; of the disseminated cases one reached a remission and all others had recurrences. In three patients the therapy could not be completed. These preliminary treatment results are believed to support the idea of a special role of the spleen in the dissemination of the disease. A new classification of clinical stages in Hodgkin's disease is proposed.
对霍奇金病患者外周血白细胞浓缩物的研究显示，在许多患者中发现了两种被认为是该疾病典型的细胞类型。脾切除术后经组织学检查确诊的脾脏受累情况与外周血中这些特征性细胞的存在密切相关。在这些病例中，这被认为是支持血行播散或疾病多中心起源的一个论据。对24例患者进行的以全淋巴结照射进行的根治性高压放疗结果似乎支持这一概念。根据Rye临床分期分类，放疗结果无法预测。II期的6例患者和III期的7例患者缓解，II期和IV期各有1例，III期的6例患者在1年内疾病复发。根据血液和脾脏检查将疾病分为局限性或播散性形式，结果显示所有局限性病例均缓解；在播散性病例中，1例缓解，其他所有病例均复发。3例患者无法完成治疗。这些初步治疗结果被认为支持脾脏在疾病播散中起特殊作用的观点。本文提出了霍奇金病临床分期的新分类。
