Musshoff K, Schmidt-Vollmer H
Br J Cancer Suppl. 1975 Mar;2:425-34.
In contrast to Hodgkin's lymphomata, non-Hodgkin's lymphomata originate in approximately a fourth of the cases in extranodal organs and sites. The prognosis of patients with primary extranodal organ involvement of the non-Hodgkin's lymphomata is similar to that of patients with primary lumph node involvement of the Hodgkin's and non-Hodgkin's lymphomata, dependent on the special spreading of the disease corresponding to the 4 stages of the Ann Arbor classification. This applies to the primary involvement of a single lymph node region (Stage I) or a single extralymphatic organ or site (stage IE) as well as to further stages of spreading within the lymphatic system (Stages II and III) including secondary localized involvement of an extralymphatic organ and site (Stages IIE and IIIE). The same qualitative dependence of the prognosis of Hodgkin's and non-Hodgkin's lymphomata on the spatial spreading, corresponding to the Ann Arbor concept, legitimizes, in spite of some quantitative differences, the application of the Ann Arbor classification system to all malignant lymphomata.
与霍奇金淋巴瘤不同，非霍奇金淋巴瘤约四分之一的病例起源于结外器官和部位。非霍奇金淋巴瘤原发性结外器官受累患者的预后，与霍奇金淋巴瘤和非霍奇金淋巴瘤原发性淋巴结受累患者的预后相似，这取决于与Ann Arbor分期系统4期相对应的疾病特殊扩散情况。这适用于单个淋巴结区域的原发性受累（I期）或单个结外器官或部位的原发性受累（IE期），以及淋巴系统内进一步的扩散阶段（II期和III期），包括结外器官和部位的继发性局限性受累（IIE期和IIIE期）。尽管存在一些数量上的差异，但霍奇金淋巴瘤和非霍奇金淋巴瘤的预后在空间扩散方面具有相同的定性依赖性，这与Ann Arbor概念相对应，使得尽管存在一些数量上的差异，但仍可将Ann Arbor分期系统应用于所有恶性淋巴瘤。
