Ford J A, Colhoun E M, McIntosh W B, Dunnigan M G
Br Med J. 1972 Jun 17;2(5815):677-80. doi: 10.1136/bmj.2.5815.677.
The prevalence of vitamin D deficiency was reassessed in April and May 1971, 10 years after the discovery of widespread late rickets and osteomalacia in the Glasgow Pakistani community. Evidence of vitamin D deficiency was found in 28 out of 115 adults and children examined (24%). Children at the age of puberty were most severely affected by rickets, whereas most infants and younger children in the survey were protected by vitamin D supplements. Mild biochemical osteomalacia was common in Pakistani women.A total of 21 Pakistani and Indian children with rickets were admitted to Glasgow hospitals during 1968-70. These comprised 10 children with infantile rickets and 11 with late rickets. Four of the latter group required osteotomy for severe rachitic deformity.Late rickets and osteomalacia in Pakistani and Indian immigrants are not primarily due to nutritional deficiency of vitamin D, though the high phytate content of their diet may be of aetiological importance. A combination of environmental, social, and endogenous factors, the relative importance of which is not at present clear, may also be involved. Advice on the prophylaxis of vitamin D deficiency should be given to all Pakistani and Indian communities in the United Kingdom.
1971年4月和5月，在格拉斯哥的巴基斯坦人群体中发现广泛存在晚发性佝偻病和骨软化症10年后，对维生素D缺乏症的患病率进行了重新评估。在接受检查的115名成人和儿童中，有28人（24%）发现存在维生素D缺乏的证据。青春期儿童受佝偻病影响最为严重，而调查中的大多数婴儿和年幼儿童因补充维生素D而受到保护。轻度生化性骨软化症在巴基斯坦女性中很常见。1968年至1970年期间，共有21名患有佝偻病的巴基斯坦和印度儿童被收治到格拉斯哥的医院。其中包括10名婴儿期佝偻病患儿和11名晚发性佝偻病患儿。后一组中有4人因严重的佝偻病畸形需要进行截骨手术。巴基斯坦和印度移民中的晚发性佝偻病和骨软化症并非主要由于维生素D的营养缺乏，尽管他们饮食中植酸盐含量高可能在病因学上具有重要意义。环境、社会和内源性因素的综合作用（目前其相对重要性尚不清楚）可能也与之有关。应该向英国所有巴基斯坦和印度社区提供预防维生素D缺乏症的建议。
