硝西泮对慢性阻塞性支气管炎的作用。
Effect of nitrazepam in chronic obstructive bronchitis.
作者信息
Gaddie J, Legge J S, Palmer K N, Petrie J C, Wood R A
出版信息
Br Med J. 1972 Jun 17;2(5815):688-9. doi: 10.1136/bmj.2.5815.688.
Abstract
The effect of nitrazepam on ventilatory capacity and arterial blood gas tensions was studied in a double-blind controlled crossover trial in six patients with chronic obstructive bronchitis in ventilatory failure (raised Paco(2)). Nitrazepam produced a fall in ventilatory capacity and worsening of the ventilatory failure. In the sixth patient, while on the active drug, the Pao(2) fell from 48 to 35 mm Hg while the Paco(2) tension rose from 59.5 to 68 mm Hg. It is suggested that nitrazepam is contraindicated in patients with severe chronic obstructive bronchitis.
摘要
在一项双盲对照交叉试验中，对6例慢性阻塞性支气管炎伴通气衰竭（动脉血二氧化碳分压升高）患者研究了硝西泮对通气能力和动脉血气张力的影响。硝西泮导致通气能力下降，通气衰竭加重。在第6例患者中，服用活性药物时，动脉血氧分压从48毫米汞柱降至35毫米汞柱，而动脉血二氧化碳分压从59.5毫米汞柱升至68毫米汞柱。提示重度慢性阻塞性支气管炎患者禁用硝西泮。
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