Leitch A G, Clancy L J, Leggett R J, Tweeddale P, Dawson P, Evans J I
Thorax. 1976 Dec;31(6):730-5. doi: 10.1136/thx.31.6.730.
We have studied arterial PO2, PCO2, and hydrogen ion and electroencephalogram during sleep in 10 patients with stable severe chronic respiratory failure. As a group the patients slept badly. Sleep was associated with a worsening of hypoxia and no significant change in PCO2 and H+. Two patients were restudied, receiving oxygen therapy overnight. Both had improved sleep but one, who had an intact hypoxic drive to breathing, developed marked hypercapnia and acidosis when his PO2 was restored to normal during sleep; the other, who had no hypoxic drive to breathing, developed no more hypercapnia or acidosis during sleep when breathing oxygen than when breathing air. Oxygen therapy may improve sleep disturbance in these patients, but its effect on the drive to breathing during sleep should be considered if severe hypercapnia and acidosis are to be avoided.
我们研究了10例稳定的严重慢性呼吸衰竭患者睡眠期间的动脉血氧分压（PO2）、二氧化碳分压（PCO2）、氢离子浓度及脑电图。总体而言，这些患者睡眠质量差。睡眠与缺氧加重相关，而PCO2和H+无显著变化。对两名患者进行了再次研究，他们接受了夜间氧疗。两人睡眠均有改善，但其中一名对呼吸有完整低氧驱动的患者，睡眠期间当PO2恢复正常时出现了明显的高碳酸血症和酸中毒；另一名对呼吸无低氧驱动的患者，睡眠期间吸氧时与呼吸空气时相比，未出现更多的高碳酸血症或酸中毒。氧疗可能改善这些患者的睡眠障碍，但如果要避免严重的高碳酸血症和酸中毒，应考虑其对睡眠期间呼吸驱动的影响。
