Geddes D M, Rudolf M, Saunders K B
Thorax. 1976 Oct;31(5):548-51. doi: 10.1136/thx.31.5.548.
Ventilatory response to CO2 was measured before and after two different benzodiazepine hypnotics in both chronic bronchitics and patients without chest disease. Flurazepam, but not nitrazepam, produced a significant decrease in CO2 sensitivity, although there was no significant change in FEV1 or mixed venous PCO2. This is the first unequivocal evidence of central depression of respiration by a benzodiazepine and may be the mechanism by which benzodiazepines cause deterioration in patients with respiratory failure.
在慢性支气管炎患者和无胸部疾病的患者中，分别测量了两种不同苯二氮䓬类催眠药使用前后对二氧化碳的通气反应。氟西泮而非硝西泮，使二氧化碳敏感性显著降低，尽管第一秒用力呼气量（FEV1）或混合静脉血二氧化碳分压（PCO2）无显著变化。这是苯二氮䓬类药物对呼吸中枢抑制作用的首个明确证据，可能是苯二氮䓬类药物导致呼吸衰竭患者病情恶化的机制。
