硝西泮和氟西泮对二氧化碳通气反应的影响。
Effect of nitrazepam and flurazepam on the ventilatory response to carbon dioxide.
作者信息
Geddes D M, Rudolf M, Saunders K B
出版信息
Thorax. 1976 Oct;31(5):548-51. doi: 10.1136/thx.31.5.548.
Abstract
Ventilatory response to CO2 was measured before and after two different benzodiazepine hypnotics in both chronic bronchitics and patients without chest disease. Flurazepam, but not nitrazepam, produced a significant decrease in CO2 sensitivity, although there was no significant change in FEV1 or mixed venous PCO2. This is the first unequivocal evidence of central depression of respiration by a benzodiazepine and may be the mechanism by which benzodiazepines cause deterioration in patients with respiratory failure.
摘要
在慢性支气管炎患者和无胸部疾病的患者中，分别测量了两种不同苯二氮䓬类催眠药使用前后对二氧化碳的通气反应。氟西泮而非硝西泮，使二氧化碳敏感性显著降低，尽管第一秒用力呼气量（FEV1）或混合静脉血二氧化碳分压（PCO2）无显著变化。这是苯二氮䓬类药物对呼吸中枢抑制作用的首个明确证据，可能是苯二氮䓬类药物导致呼吸衰竭患者病情恶化的机制。
相似文献
1
Effect of nitrazepam and flurazepam on the ventilatory response to carbon dioxide.硝西泮和氟西泮对二氧化碳通气反应的影响。
Thorax. 1976 Oct;31(5):548-51. doi: 10.1136/thx.31.5.548.
2
Depression of central respiratory drive by nitrazepam.硝西泮对中枢呼吸驱动的抑制作用。
Thorax. 1978 Feb;33(1):97-100. doi: 10.1136/thx.33.1.97.
3
Comparison of the residual effects of two benzodiazepines (nitrazepam and flurazepam hydrochloride) and pentobarbitone sodium on human performance.两种苯二氮䓬类药物（硝西泮和盐酸氟西泮）及戊巴比妥钠对人体机能残余效应的比较。
Br J Clin Pharmacol. 1975 Feb;2(1):9-17. doi: 10.1111/j.1365-2125.1975.tb00465.x.
4
The automated assessment of the effect of flurazepam and nitrazepam on mood state.氟西泮和硝西泮对情绪状态影响的自动评估。
Acta Psychiatr Scand. 1975 Mar;51(3):201-9. doi: 10.1111/j.1600-0447.1975.tb00005.x.
5
Inhibitory and disinhibitory effects of nitrazepam, diazepam and flurazepam hydrochloride on delayed matching behaviour in monkeys (Macaca mulatta).硝西泮、地西泮和盐酸氟西泮对猕猴（恒河猴）延迟匹配行为的抑制和去抑制作用。
Neuropharmacology. 1974 Nov;13(10-11):919-26. doi: 10.1016/0028-3908(74)90083-5.
6
A double blind trial of nitrazepam and flurazepam as sedatives.硝西泮和氟西泮作为镇静剂的双盲试验。
N Z Med J. 1975 Mar 12;81(535):246-8.
7
[Effect of intravenous nitrazepam on pulmonary ventilation and on the ventilatory response to CO2].[静脉注射硝西泮对肺通气及对二氧化碳通气反应的影响]
Minerva Anestesiol. 1973 Nov;39(11):498-508.
8
Effect of nitrazepam in chronic obstructive bronchitis.硝西泮对慢性阻塞性支气管炎的作用。
Br Med J. 1972 Jun 17;2(5815):688-9. doi: 10.1136/bmj.2.5815.688.
9
A repeated dose comparison of three benzodiazepine derivative (nitrazepam, flurazepam and flunitrazepam) on subjective appraisals of sleep and measures of psychomotor performance the morning following night-time medication.三种苯二氮䓬衍生物（硝西泮、氟西泮和氟硝西泮）重复给药对夜间用药后早晨睡眠主观评价及精神运动表现指标的比较。
Acta Psychiatr Scand. 1977 Nov;56(5):373-81. doi: 10.1111/j.1600-0447.1977.tb06678.x.
10
Residual effects of hypnotics: triazolam, flurazepam, and nitrazepam.催眠药的残留效应：三唑仑、氟西泮和硝西泮。
Psychopharmacology (Berl). 1980;68(1):61-5. doi: 10.1007/BF00426651.
引用本文的文献
1
Benzodiazepine Prescribing in People with Chronic Obstructive Pulmonary Disease: Clinical Considerations.苯二氮䓬类药物在慢性阻塞性肺疾病患者中的处方：临床考虑。
Drugs Aging. 2020 Apr;37(4):263-270. doi: 10.1007/s40266-020-00756-z.
2
Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults.苯二氮䓬类药物用于缓解成人晚期恶性和非恶性疾病中的呼吸困难。
Cochrane Database Syst Rev. 2016 Oct 20;10(10):CD007354. doi: 10.1002/14651858.CD007354.pub3.
3
[Sleep, respiration and benzodiazepines: effects of benzodiazepines on nocturnal respiration].[睡眠、呼吸与苯二氮䓬类药物：苯二氮䓬类药物对夜间呼吸的影响]
J Psychiatry Neurosci. 1995 May;20(3):178-84.
4
Methods in the assessment of the control of breathing.呼吸控制评估方法。
Br J Clin Pharmacol. 1980 Jan;9(1):3-9. doi: 10.1111/j.1365-2125.1980.tb04789.x.
5
Hypnotics and the control of breathing: a review.催眠药与呼吸控制：综述
Br J Clin Pharmacol. 1983;16 Suppl 2(Suppl 2):245S-250S. doi: 10.1111/j.1365-2125.1983.tb02296.x.
6
Psychomotor, pulmonary and exercise responses to sleep medication.对睡眠药物的精神运动、肺部及运动反应。
Br J Clin Pharmacol. 1987 Aug;24(2):191-7. doi: 10.1111/j.1365-2125.1987.tb03161.x.
7
Effect of diazepam on sleep in patients with chronic airflow obstruction.地西泮对慢性气流阻塞患者睡眠的影响。
Thorax. 1988 Sep;43(9):729-30. doi: 10.1136/thx.43.9.729.
8
A comparison of the effects of zolpidem and placebo on respiration and oxygen saturation during sleep in the healthy elderly.唑吡坦与安慰剂对健康老年人睡眠期间呼吸及血氧饱和度影响的比较
Br J Clin Pharmacol. 1990 Dec;30(6):817-24. doi: 10.1111/j.1365-2125.1990.tb05446.x.
9
Effects of estazolam and flurazepam on cardiopulmonary function in patients with chronic obstructive pulmonary disease.艾司唑仑和氟西泮对慢性阻塞性肺疾病患者心肺功能的影响。
Drug Saf. 1992 Mar-Apr;7(2):152-8. doi: 10.2165/00002018-199207020-00006.
10
Depression of central respiratory drive by nitrazepam.硝西泮对中枢呼吸驱动的抑制作用。
Thorax. 1978 Feb;33(1):97-100. doi: 10.1136/thx.33.1.97.
本文引用的文献
1
EFFECTS OF CHLORDIAZEPOXIDE AND DIAZEPAM ON THE INFLUENCE OF MEPERIDINE ON THE RESPIRATORY RESPONSE TO CARBON DIOXIDE.氯氮䓬和地西泮对哌替啶影响二氧化碳呼吸反应的作用
J New Drugs. 1965 Mar-Apr;5(2):121-4. doi: 10.1002/j.1552-4604.1965.tb00236.x.
2
Rebreathing method for measurement of mixed venous PCO2.用于测量混合静脉血二氧化碳分压的重呼吸法。
Br Med J. 1962 Sep 8;2(5305):630-3. doi: 10.1136/bmj.2.5305.630.
3
A clinical method for assessing the ventilatory response to carbon dioxide.一种评估对二氧化碳通气反应的临床方法。
Australas Ann Med. 1967 Feb;16(1):20-32. doi: 10.1111/imj.1967.16.1.20.
4
The effect of diazepam on the respiratory response to carbon dioxide.地西泮对二氧化碳呼吸反应的影响。
Can Anaesth Soc J. 1966 Jul;13(4):374-7. doi: 10.1007/BF03002179.
5
Effect of diazepam and meperidine, alone and in combination, on respiratory response to carbon dioxide.地西泮和哌替啶单独及联合使用对二氧化碳呼吸反应的影响。
Anesth Analg. 1969 May-Jun;48(3):353-5.
6
The effects of diazepam on respiration in patients with obstructive pulmonary disease.地西泮对阻塞性肺疾病患者呼吸的影响。
Anesthesiology. 1971 Jan;34(1):14-8. doi: 10.1097/00000542-197101000-00006.
7
Nitrazepam in chronic obstructive bronchitis.硝西泮用于慢性阻塞性支气管炎的治疗。
Br Med J. 1972 Aug 5;3(5822):352. doi: 10.1136/bmj.3.5822.352-c.
8
Effect of nitrazepam in chronic obstructive bronchitis.硝西泮对慢性阻塞性支气管炎的作用。
Br Med J. 1972 Jun 17;2(5815):688-9. doi: 10.1136/bmj.2.5815.688.
9
Nitrazepam--a safe hypnotic.硝西泮——一种安全的催眠药。
Br Med J. 1969 Jul 5;3(5661):23-5. doi: 10.1136/bmj.3.5661.23.
10
Nitrazepam induced respiratory depression in chronic obstructive lung disease.硝西泮可诱发慢性阻塞性肺疾病患者出现呼吸抑制。
Br J Dis Chest. 1973 Apr;67(2):128-30. doi: 10.1016/0007-0971(73)90042-9.
Zotero 插件