Rudolf M, Geddes D M, Turner J A, Saunders K B
Thorax. 1978 Feb;33(1):97-100. doi: 10.1136/thx.33.1.97.
In a group of patients with chronic bronchitis, repeated night sedation with 10 mg nitrazepam produced a fall in central respiratory drive and a steady rise in arterial carbon dioxide tension. The changes produced over a five-day period were not clinically important, except in two patients who were already hypercapnic before receiving nitrazepam. The use of this drug in patients with carbon dioxide retention should be avoided.
在一组慢性支气管炎患者中，每晚重复服用10毫克硝西泮进行镇静会导致中枢呼吸驱动力下降，动脉血二氧化碳分压持续升高。在五天时间内产生的这些变化在临床上并不重要，只有两名在服用硝西泮之前就已经存在高碳酸血症的患者除外。应避免在有二氧化碳潴留的患者中使用这种药物。
