Lal S, Mendis T, Cervantes P, Guyda H, DeRivera J L
Neuropsychobiology. 1979;5(6):327-31. doi: 10.1159/000117699.
The effect of benztropine on haloperidol-induced prolactin secretion was investigated in 10 normal male volunteers. Benztropine had no effect on basal prolactin secretion but significantly enhanced the increased induced by haloperidol. The magnitude of the enhancement, however, was relatively small. These data suggest that in man cholinergic mechanisms have no effect on basal prolactin secretion but exert a weak inhibitory effect under conditions of dopamine receptor blockade. Differences in intrinsic anticholinergic properties may account for some of the variations in potency of different neuroleptics in increasing circulating prolactin concentrations.
在10名正常男性志愿者中研究了苯海索对氟哌啶醇诱导的催乳素分泌的影响。苯海索对基础催乳素分泌没有影响，但显著增强了氟哌啶醇诱导的催乳素分泌增加。然而，增强的幅度相对较小。这些数据表明，在人类中，胆碱能机制对基础催乳素分泌没有影响，但在多巴胺受体阻断的情况下发挥微弱的抑制作用。内在抗胆碱能特性的差异可能解释了不同抗精神病药物在增加循环催乳素浓度方面效力的一些差异。
