Rinieris P, Hatzimanolis J, Markianos M, Stefanis C
Department of Psychiatry, Athens University Medical School, Eginition Hospital, Greece.
Eur Arch Psychiatry Neurol Sci. 1988;237(4):189-93. doi: 10.1007/BF00449905.
Serum prolactin (PRL), luteinizing hormone (LH) and testosterone (T) levels were estimated in a group of 30 male paranoid schizophrenics before and after 4 weeks treatment with chlorpromazine and/or trihexyphenidyl, and in a group of 14 healthy male individuals. After treatment with chlorpromazine (100 mg t.i.d., p.o.), 10 patients presented a significant increase in serum PRL values and a significant decrease in serum T values. A significant increase in serum PRL values was also found in 10 patients who were treated with chlorpromazine (100 mg t.i.d., p.o.) plus trihexyphenidyl (5 mg t.i.d., p.o.). No significant difference in any of the investigated endocrine parameters was detected in 10 patients after 4 weeks administration of trihexyphenidyl (5 mg t.i.d., p.o.). Following chlorpromazine treatment with or without concomitant administration of trihexyphenidyl, 20 patients showed a significant increase in serum PRL levels and a significant decrease in serum LH and T levels.
对30名男性偏执型精神分裂症患者在使用氯丙嗪和/或苯海索治疗4周前后以及14名健康男性个体的血清催乳素（PRL）、促黄体生成素（LH）和睾酮（T）水平进行了评估。在用氯丙嗪（口服，每日3次，每次100 mg）治疗后，10名患者的血清PRL值显著升高，血清T值显著降低。在接受氯丙嗪（口服，每日3次，每次100 mg）加苯海索（口服，每日3次，每次5 mg）治疗的10名患者中，也发现血清PRL值显著升高。在10名患者口服苯海索（每日3次，每次5 mg）4周后，未检测到任何所研究的内分泌参数有显著差异。在用氯丙嗪治疗且不论是否同时服用苯海索后，20名患者的血清PRL水平显著升高，血清LH和T水平显著降低。
