淋病奈瑟菌菌毛的免疫异质性

Immunological heterogeneity of pili of Neisseria gonorrhoeae.

作者信息

Novotny P, Turner W H

出版信息

J Gen Microbiol. 1975 Jul;89(1):87-92. doi: 10.1099/00221287-89-1-87.

Abstract

Sera of rabbits immunized with pili or formalized cultures of Neisseria gonorrhoeae contained pili antibodies. The reaction between pili and specific gamma globulin was followed by direct visual observation with an electron microscope. Using pili from 31 strains and antisera against three strains, only a few crossreactions between pili were observed. From this it is concluded that gonococcal pili are antigenically heterogeneous. However, serum raised with a T3 culture (with no detectable pili) contained antibodies against pili of the homologous T2 strain. It is proposed that the pilus antigen may exist in a form different from the typical pilus in gonococci.

摘要

用淋病奈瑟菌菌毛或经甲醛处理的培养物免疫的兔血清中含有菌毛抗体。菌毛与特异性γ球蛋白之间的反应通过电子显微镜直接观察。使用来自31株菌株的菌毛和针对三株菌株的抗血清，仅观察到少数菌毛之间的交叉反应。由此得出结论，淋球菌菌毛在抗原性上是异质的。然而，用T3培养物（无可检测到的菌毛）产生的血清含有针对同源T2菌株菌毛的抗体。有人提出，菌毛抗原可能以不同于淋球菌中典型菌毛的形式存在。