Novotny P, Broughton E S, Cownley K, Hughes M, Turner W H
Br J Vener Dis. 1978 Apr;54(2):88-96. doi: 10.1136/sti.54.2.88.
The ability of gonococci to infect the subcutaneous chamber in guinea-pigs is strictly strain related. This ability was usually present in prototrophic strains and auxotrophs requiring proline only which were obtained from patients with uncomplicated gonorrhoea, but it was invariably absent in Neisseria gonorrhoeae auxotypes requiring arginine, uracil, and hypoxanthine, or arginine only for growth. All the strains obtained from disseminated gonococcal infections (all dependent upon arginine, uracil, and hypoxanthine) were unable to infect the guinea-pig chamber. Hence, the high invasiveness of N. gonorrhoeae for man and its infectivity for guinea-pig chambers appear to be unrelated properties. Although guinea-pigs of the same origin (Dunkin-Hartley) were used throughout, the degree of immune resistance was found to differ between the lines supplied by various breeders--that is, after a standard immunisation schedule using whole cell gonococcal vaccines, the homologous immune resistance to challenge varied from weak or non-existent in some lines, to highly resistant in others.
淋球菌感染豚鼠皮下腔室的能力与菌株密切相关。这种能力通常存在于原养型菌株和仅需脯氨酸的营养缺陷型菌株中，这些菌株取自无并发症淋病患者，但在生长需要精氨酸、尿嘧啶和次黄嘌呤或仅需精氨酸的淋病奈瑟菌营养型中则始终不存在。所有从播散性淋球菌感染中分离出的菌株（均依赖精氨酸、尿嘧啶和次黄嘌呤）都无法感染豚鼠腔室。因此，淋病奈瑟菌对人类的高侵袭性及其对豚鼠腔室的感染性似乎是不相关的特性。尽管在整个实验过程中使用的是同一来源（邓金 - 哈特利）的豚鼠，但发现不同饲养者提供的品系之间免疫抵抗力程度有所不同——也就是说，在使用全细胞淋球菌疫苗进行标准免疫程序后，对攻击的同源免疫抵抗力在某些品系中较弱或不存在，而在其他品系中则具有高度抗性。
