全身性牛痘病毒感染的恢复机制。I. 环磷酰胺的作用
Mechanism of recovery from systemic vaccinia virus infection. I. The effects of cyclophosphamide.
作者信息
Worthington M, Rabson A S, Baron S
出版信息
J Exp Med. 1972 Aug 1;136(2):277-90. doi: 10.1084/jem.136.2.277.
Abstract
Administration of Cytoxan in doses capable of inhibiting both humoral and cellular immunity markedly potentiated primary systemic vaccinia virus infection in mice. Immunosuppressed mice did not form neutralizing antibody to vaccinia virus and had a prolonged and more severe viremia than nonimmunosuppressed control mice. Passive transfer of physiologic amounts of neutralizing antibody late in the course of infection, at a time when nonimmunosuppressed mice had similar levels of serum antibody, largely reversed the effect of Cytoxan on vaccinia virus infection. Transfer of 100 million immune spleen cells was much less effective than antibody in reversing the effect of Cytoxan on vaccinia virus infection, and mice receiving these cells did make some antibody. Serum interferon levels were not affected by Cytoxan. The results suggest an essential role for humoral antibody, but not for cellular immunity, in recovery from primary vaccinia virus infection in the mouse.
摘要
给予能够抑制体液免疫和细胞免疫的剂量的环磷酰胺，可显著增强小鼠原发性全身性牛痘病毒感染。免疫抑制的小鼠未形成针对牛痘病毒的中和抗体，并且与未免疫抑制的对照小鼠相比，具有更长时间且更严重的病毒血症。在感染过程后期，当未免疫抑制的小鼠具有相似水平的血清抗体时，被动转移生理量的中和抗体在很大程度上逆转了环磷酰胺对牛痘病毒感染的影响。转移1亿个免疫脾细胞在逆转环磷酰胺对牛痘病毒感染的影响方面远不如抗体有效，并且接受这些细胞的小鼠确实产生了一些抗体。血清干扰素水平不受环磷酰胺影响。结果表明，体液抗体而非细胞免疫在小鼠原发性牛痘病毒感染的恢复中起重要作用。
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