[Course of the vaccinal process induced by the vaccinia virus in cyclophosphane-suppressed cellular and humoral immunity].

Under conditions of immunosuppression of B- and T- cell function by cyclophosphane the vaccination process in mice immunized with vaccinia virus was considerably more severe than in the untreated animals: mortality in immunosuppressed mice was much higher than in the controls; the virus could be isolated from their lungs for longer periods and in higher titres; the number of antibody-producing cells in the spleen and antibody levels in the blood were lower. In contrast to the inactivated vaccine, live vaccine itself exerted a marked immunosuppressive effect.