关于离子跨神经膜运输的理论。V. 科尔-摩尔钾离子超极化延迟的两种模型。
On the theory of ion transport across the nerve membrane. V. Two models for the Cole-Moore K + hyperpolarization delay.
作者信息
Hill T L, Chen Y D
出版信息
Biophys J. 1972 Aug;12(8):960-76. doi: 10.1016/S0006-3495(72)86137-X.
Abstract
Two illustrative molecular models, designed to explain the Cole-Moore K(+) hyperpolarization delay, are proposed and analyzed. Both introduce a process supplementary to the usual Hodgkin-Huxley (HH) one for a K(+) channel. In both cases the new process becomes involved as a consequence of the conditioning hyperpolarization of the membrane and would account for the observed delay time in the K(+) current after depolarization to near ENa. The first model uses adsorption or desorption of phospholipid molecules on the surface of the assumed protein K(+) channel or gate. The second model involves the translocation of the charged subunits of the channel in the hyperpolarizing electric field.
摘要
本文提出并分析了两个用于解释科尔-摩尔钾离子超极化延迟现象的分子模型。这两个模型均引入了一个与常规霍奇金-赫胥黎（HH）钾离子通道过程互补的过程。在这两种情况下，新过程都是由于膜的预处理超极化而产生的，并且可以解释去极化至接近ENa后钾离子电流中观察到的延迟时间。第一个模型利用磷脂分子在假定的蛋白质钾离子通道或门控表面的吸附或解吸。第二个模型涉及通道带电亚基在超极化电场中的移位。
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