β受体阻滞剂对正常人和哮喘患者通气功能影响的意义。
Significance of effect of beta blockade on ventilatory function in normal and asthmatic subjects.
作者信息
Jones R S
出版信息
Thorax. 1972 Sep;27(5):572-6. doi: 10.1136/thx.27.5.572.
Abstract
The lability index was examined in 45 normal subjects between 17 and 45 years and also in six patients with asthma, five with a history of asthma in childhood but no clinical attacks, and three with hay fever. The measurements were repeated after β blockade with propranolol. Fifteen per cent of the normal subjects exhibited a degree of lability after propranolol which has been previously found only in asthma. It is suggested that a constrictor mechanism exists in normal subjects on exercise but that β receptor activity protects them from bronchiolar constriction; post-exercise bronchoconstriction in the asthmatic may be explained in terms of this mechanism. It is also suggested that a proportion of `normal' subjects are potentially more labile than the remainder of the population and that it is these who may develop clinical asthma if they also happen to be atopic subjects.
摘要
对45名年龄在17至45岁之间的正常受试者以及6名哮喘患者、5名有儿童哮喘病史但无临床发作的患者和3名花粉热患者进行了易激性指数检测。用普萘洛尔进行β受体阻断后重复测量。15%的正常受试者在使用普萘洛尔后出现了一定程度的易激性，这种情况以前仅在哮喘患者中发现。这表明正常受试者在运动时存在一种收缩机制，但β受体活性可保护他们免受细支气管收缩的影响；哮喘患者运动后支气管收缩可以用这种机制来解释。还表明一部分“正常”受试者可能比其他人群更易激，而如果这些人恰好是特应性受试者，他们可能会发展为临床哮喘。
相似文献
1
Significance of effect of beta blockade on ventilatory function in normal and asthmatic subjects.β受体阻滞剂对正常人和哮喘患者通气功能影响的意义。
Thorax. 1972 Sep;27(5):572-6. doi: 10.1136/thx.27.5.572.
2
[Bronchoconstrictor effects of beta-adrenergic blockade in asthma: influence of baseline value (author's transl)].β-肾上腺素能阻滞剂在哮喘中的支气管收缩作用：基线值的影响（作者译）
Respiration. 1974 Jan;31(1):21-37. doi: 10.1159/000193096.
3
Exercise-induced airways constriction.运动诱发的气道收缩
Thorax. 1972 Mar;27(2):169-80. doi: 10.1136/thx.27.2.169.
4
Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma.静脉注射AH 5158（异丁酰咪胺）与普萘洛尔治疗哮喘的比较。
Br Med J. 1975 Apr 12;2(5962):59-61. doi: 10.1136/bmj.2.5962.59.
5
The relationship of leucocyte adenyl cyclase activity and airways response to beta blockade and allergen challenge in extrinsic asthma.外源性哮喘中白细胞腺苷酸环化酶活性与气道对β受体阻滞剂及过敏原激发反应的关系。
Clin Allergy. 1974 Sep;4(3):311-22. doi: 10.1111/j.1365-2222.1974.tb01391.x.
6
7
The airways response to phenylephrine after blockade of alpha and beta receptors in extrinsic bronchial asthma.外源性支气管哮喘患者α和β受体阻断后气道对去氧肾上腺素的反应。
Clin Allergy. 1973 Dec;3(4):439-48. doi: 10.1111/j.1365-2222.1973.tb01351.x.
8
The effect of beta adrenergic blockade on bronchial sensitivity to acetyl-beta-methacholine in normal and allergic rhinitis subjects.β-肾上腺素能阻滞剂对正常人和变应性鼻炎患者支气管对乙酰-β-甲基胆碱敏感性的影响。
J Allergy Clin Immunol. 1976 Apr;57(4):358-66. doi: 10.1016/0091-6749(76)90093-2.
9
[Bronchomotor reactions of the normal person after blocking of the beta-adrenergic receptors].[正常人β-肾上腺素能受体阻断后支气管运动反应]
Acta Allergol. 1968 Feb;23(1):11-7.
10
In vivo and in vitro studies on alpha-receptors in human airways. Potentiation with bacterial endotoxin.人体气道中α受体的体内和体外研究。细菌内毒素的增强作用。
Scand J Respir Dis. 1972;53(4):227-36.
引用本文的文献
1
Mechanisms of sulphur dioxide induced bronchoconstriction in normal and asthmatic man.二氧化硫在正常人和哮喘患者中诱发支气管收缩的机制。
Thorax. 1982 Feb;37(2):118-23. doi: 10.1136/thx.37.2.118.
2
Plasma cyclic nucleotide levels in exercise-induced asthma.运动诱发性哮喘患者的血浆环核苷酸水平
Thorax. 1981 Nov;36(11):823-7. doi: 10.1136/thx.36.11.823.
3
Exercise-induced asthma.运动诱发性哮喘
Clin Rev Allergy. 1983 Mar;1(1):19-37. doi: 10.1007/BF02991315.
4
The effects of pafenolol and metoprolol on ventilatory function and haemodynamics during exercise by asthmatic patients.帕非洛尔和美托洛尔对哮喘患者运动期间通气功能和血流动力学的影响。
Eur J Clin Pharmacol. 1983;24(3):289-95. doi: 10.1007/BF00610043.
5
Adverse effects of beta-adrenergic receptor blocking drugs on respiratory function.β-肾上腺素能受体阻断药对呼吸功能的不良反应。
Drugs. 1974;7(1):130-8. doi: 10.2165/00003495-197407010-00009.
6
Influence of intrinsic sympathomimetic activity on respiratory function during chronic beta blockade: comparison of propranolol and pindolol.慢性β受体阻滞剂治疗期间内在拟交感活性对呼吸功能的影响：普萘洛尔与吲哚洛尔的比较
Br Med J (Clin Res Ed). 1986 Jul 12;293(6539):97-9. doi: 10.1136/bmj.293.6539.97.
7
Beta-adrenergic function in airways of healthy and asthmatic subjects.健康受试者和哮喘患者气道中的β-肾上腺素能功能
Thorax. 1975 Dec;30(6):657-62. doi: 10.1136/thx.30.6.657.
8
Bronchoconstriction in potroom workers.电解车间工人的支气管收缩
Br J Ind Med. 1979 Aug;36(3):211-5. doi: 10.1136/oem.36.3.211.
9
Effect in bronchial asthma of a new beta-adrenergic blocking drug atenolol (ICI 66, 082).新型β-肾上腺素能阻滞剂阿替洛尔（ICI 66,082）对支气管哮喘的作用
Eur J Clin Pharmacol. 1977;11(1):11-4. doi: 10.1007/BF00561781.
10
Effect of atenolol on ventilatory and cardiac function in asthma.阿替洛尔对哮喘患者通气和心脏功能的影响。
Br Med J. 1976 Aug 21;2(6033):453-5. doi: 10.1136/bmj.2.6033.453.
本文引用的文献
1
The effect of exercise on ventilatory function in the child with asthma.运动对哮喘患儿通气功能的影响。
Br J Dis Chest. 1962 Apr;56:78-86. doi: 10.1016/s0007-0971(62)80005-9.
2
EFFECT OF A BETA-ADRENERGIC-BLOCKING AGENT, PROPRANOLOL, ON ASTHMATICS.β-肾上腺素能阻滞剂普萘洛尔对哮喘患者的影响。
Lancet. 1964 Nov 21;2(7369):1101-2. doi: 10.1016/s0140-6736(64)92617-0.
3
THE PLACE OF PHYSICAL EXERCISE AND BRONCHODILATOR DRUGS IN THE ASSESSMENT OF THE ASTHMATIC CHILD.体育锻炼和支气管扩张剂药物在哮喘儿童评估中的作用
Arch Dis Child. 1963 Dec;38(202):539-45. doi: 10.1136/adc.38.202.539.
4
Effect of propranolol on ventilatory function.普萘洛尔对通气功能的影响。
Am J Cardiol. 1966 Sep;18(3):473-5. doi: 10.1016/0002-9149(66)90072-5.
5
Exercise-induced asthma.运动诱发性哮喘
Br Med J. 1969 Sep 6;3(5670):556-8. doi: 10.1136/bmj.3.5670.556.
6
Resistance to breathing during exercise-induced asthma attacks.运动诱发哮喘发作时的呼吸阻力。
Am Rev Respir Dis. 1970 Jun;101(6):885-96. doi: 10.1164/arrd.1970.101.6.885.
7
Dyspnea and bronchospasm from inappropriate postexercise hyperventilation.运动后不适当的过度通气引起的呼吸困难和支气管痉挛。
Ann Intern Med. 1969 Dec;71(6):1063-72. doi: 10.7326/0003-4819-71-6-1063.
8
The role of cyclic-3',5'-AMP in responses to catecholamines and other hormones.环3',5'-腺苷酸在对儿茶酚胺及其他激素反应中的作用。
Pharmacol Rev. 1966 Mar;18(1):145-61.
9
Effect of alpha-receptor blocking drugs and disodium cromoglyate on histamine hypersensitivity in bronchial asthma.α受体阻断药和色甘酸钠对支气管哮喘组胺超敏反应的影响。
Br Med J. 1970 Apr 18;2(5702):139-41. doi: 10.1136/bmj.2.5702.139.
10
Exercise-induced asthma.运动诱发性哮喘
Q J Med. 1966 Jan;35(137):55-67.
Zotero 插件