静脉注射AH 5158（异丁酰咪胺）与普萘洛尔治疗哮喘的比较。
Comparison of intravenous AH 5158 (ibidomide) and propranolol in asthma.
作者信息
Skinner C, Gaddie J, Palmer K N
出版信息
Br Med J. 1975 Apr 12;2(5962):59-61. doi: 10.1136/bmj.2.5962.59.
Abstract
The cardiac and bronchial effects of AH 5158 and propranolol were compared in a double-blind, placebocontrolled intravenous study on 10 asthmatics. AH 5158, like propranolol, is a non-cardioselective beta-adrenoceptor-blocking drug, but unlike propranolol it also has an alpha-adrenoceptor-blocking action. Both drugs produced equivalent cardiac(beta1) blockade, but propranolol produced bronchoconstriction, whereas AH 5158 did not. Hence the alpha-blocking action of AH 5158 seems to prevent the bronchoconstrictor effects of propranolol in these patients.
摘要
在一项针对10名哮喘患者的双盲、安慰剂对照静脉注射研究中，对AH 5158和普萘洛尔的心脏及支气管效应进行了比较。AH 5158与普萘洛尔一样，是一种非心脏选择性β-肾上腺素受体阻断药，但与普萘洛尔不同的是，它还具有α-肾上腺素受体阻断作用。两种药物产生了等效的心脏（β1）阻断作用，但普萘洛尔引起了支气管收缩，而AH 5158没有。因此，AH 5158的α阻断作用似乎可预防普萘洛尔对这些患者的支气管收缩效应。
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