Timio M, Gentili S, Pede S
Br Heart J. 1979 Oct;42(4):471-4. doi: 10.1136/hrt.42.4.471.
Urinary levels of free adrenaline and noradrenaline were measured in two groups of healthy male industrial workers exposed to alternate four-day periods of working conditions with and without time stress, to test the hypothesis that the sympathetic nervous system is overactivated by occupational stress. Thirty confectionary workers alternated piece-work (payment by results) and work with a fixed daily wage while 30 metal workers alternated work on an assembly line with work off it. Under time stress urinary free adrenaline was 450 per cent and noradrenaline 230 per cent of the levels for similar work without time stress but involving equal oxygen consumption. These differences were statistically highly significant and they persisted on retesting after six months of alternating work regimens. They support the concept that occupational stress in industrial workers influences the adrenosympathetic system and they indicate a possible method for assessing the effects of high levels of sympathetic activity on the aetiology of ischaemic heart disease.
对两组健康男性产业工人的尿中游离肾上腺素和去甲肾上腺素水平进行了测量，这两组工人交替经历为期四天的有时间压力和无时间压力的工作条件，以检验交感神经系统会因职业压力而过度激活这一假设。30名糖果工人交替进行计件工作（按成果计酬）和拿固定日薪的工作，而30名金属工人则在装配线上工作和脱离装配线工作之间交替。在有时间压力的情况下，尿中游离肾上腺素水平是无时间压力但耗氧量相同的类似工作的450%，去甲肾上腺素水平是其230%。这些差异在统计学上具有高度显著性，并且在工作方案交替六个月后重新测试时依然存在。它们支持了产业工人的职业压力会影响肾上腺交感系统这一概念，并且表明了一种评估高水平交感神经活动对缺血性心脏病病因学影响的可能方法。
