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[急救人员和医生在快速反应期间血液和尿液中游离儿茶酚胺的行为]

[Behavior of free catecholamines in blood and urine of ambulance men and physicians during quick responses].

作者信息

Lehmann M, Dörges V, Huber G, Zöllner G, Spöri U, Keul J

出版信息

Int Arch Occup Environ Health. 1983;51(3):209-22. doi: 10.1007/BF00377753.

Abstract

Free urine adrenaline, noradrenaline, (additional free plasma catecholamines in the physicians), and blood lactate were determined in 11 ambulance men and 5 physicians to assess stress during medical service. Stress was evaluated employing a stress index, based on difficulties in driving, traffic, severity of injuries or illness. Emergency cases with seriously injured subjects or reanimation were judged to have a 4-fold higher stress index than routine cases where strong physiological or psychological stress was absent. Urine catecholamines and stress indices were estimated in 3-h intervals. The calculations were based on the stress induced catecholamine concentrations minus the basal excretion during the same 3-h interval. Urine adrenaline and noradrenaline in ambulance men and physicians correlated directly with the stress index, as well as the plasma catecholamines of the physicians. Lactate levels showed similar behaviour and a descriptive direct correlation with the plasma catecholamines. Urine adrenaline increased more--dependent on the stress index--than urine noradrenaline. This over-proportional adrenaline response may be an indicator for the additional psychological stress in emergency cases. Therefore physicians showed--based on the same stress index--a tendency to higher urine adrenaline excretion and blood lactate levels than the ambulance men, which might be the consequence of the overall responsibility of the physicians. Because of the observed catecholamine responses during medical service, coronary insufficiency or hypertension might be contra-indications for participation in the medical service; regular clinical investigations including ergometric tests are advisable.

摘要

对11名急救人员和5名医生测定了尿肾上腺素、去甲肾上腺素(医生还测定了游离血浆儿茶酚胺)和血乳酸,以评估医疗服务期间的应激情况。采用基于驾驶困难、交通状况、损伤或疾病严重程度的应激指数来评估应激。伴有重伤患者或复苏的急诊病例的应激指数被判定为比无强烈生理或心理应激的常规病例高4倍。每隔3小时估算一次尿儿茶酚胺和应激指数。计算基于应激诱导的儿茶酚胺浓度减去同一3小时间隔内的基础排泄量。急救人员和医生的尿肾上腺素和去甲肾上腺素与应激指数直接相关,医生的血浆儿茶酚胺也与应激指数直接相关。乳酸水平表现出类似的情况,并且与血浆儿茶酚胺呈描述性直接相关。尿肾上腺素的增加幅度更大——取决于应激指数——比尿去甲肾上腺素大。这种肾上腺素的过度反应可能是急诊病例中额外心理应激的一个指标。因此,基于相同的应激指数,医生比急救人员有更高的尿肾上腺素排泄量和血乳酸水平的倾向,这可能是医生总体责任的结果。由于在医疗服务期间观察到儿茶酚胺反应,冠状动脉供血不足或高血压可能是参与医疗服务的禁忌症;建议进行包括测力计测试在内的定期临床检查。

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