小鼠莫洛尼病毒诱导肿瘤的研究：I. 通过抗体介导的细胞毒性检测p30作为小鼠莫洛尼白血病脾细胞和体外莫洛尼肉瘤细胞系上的细胞毒性靶点。
Studies on mouse Moloney virus induced tumours: I. The detection of p30 as a cytotoxic target on murine Moloney leukaemic spleen cells, and on an in vitro Moloney sarcoma line by antibody mediated cytotoxicity.
作者信息
Epstein L B, Knight R A
出版信息
Br J Cancer. 1975 May;31(5):499-512. doi: 10.1038/bjc.1975.90.
Abstract
Antigenic determinants of p30, the most abundant internal virion protein of C type RNA viruses, were detected on the surface of spleen cells from mice bearing Moloney leukaemia and on an in vitro line of Moloney sarcoma, MSC. On both cell types, these determinants on the p30 molecules served as cytotoxic targets in a xenogenic complement dependent antibody mediated 51Cr release assay. Two antisera were used: a rat anti MLV -M induced lymphoma serum, and an antiserum raised in goats to either disrupted FeLV. The cytotoxic target antigens of these antisera were analysed by inhibition of cytotoxicity with viral and cellular proteins.
摘要
p30是C型RNA病毒中最丰富的内部病毒粒子蛋白，在患有莫洛尼白血病的小鼠脾脏细胞表面以及莫洛尼肉瘤体外细胞系MSC上检测到了其抗原决定簇。在这两种细胞类型上，p30分子上的这些抗原决定簇在异种补体依赖性抗体介导的51Cr释放试验中作为细胞毒性靶标。使用了两种抗血清：一种大鼠抗MLV -M诱导的淋巴瘤血清，以及一种用山羊制备的针对灭活猫白血病病毒的抗血清。通过用病毒蛋白和细胞蛋白抑制细胞毒性来分析这些抗血清的细胞毒性靶标抗原。
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Studies on mouse Moloney virus induced tumours: I. The detection of p30 as a cytotoxic target on murine Moloney leukaemic spleen cells, and on an in vitro Moloney sarcoma line by antibody mediated cytotoxicity.小鼠莫洛尼病毒诱导肿瘤的研究：I. 通过抗体介导的细胞毒性检测p30作为小鼠莫洛尼白血病脾细胞和体外莫洛尼肉瘤细胞系上的细胞毒性靶点。
Br J Cancer. 1975 May;31(5):499-512. doi: 10.1038/bjc.1975.90.
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Studies on mouse Moloney virus induced tumours: II. Detection of p30 in the serum of mice with Moloney leukaemia by in vitro blocking of complement dependent antibody mediated cytotoxicity.小鼠莫洛尼病毒诱导肿瘤的研究：II. 通过体外阻断补体依赖性抗体介导的细胞毒性检测莫洛尼白血病小鼠血清中的p30
Br J Cancer. 1975 May;31(5):513-23. doi: 10.1038/bjc.1975.91.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.用于估计小鼠细胞毒素的51铬释放试验的扩展。
Transplantation. 1968 Sep;6(6):761-4. doi: 10.1097/00007890-196809000-00002.
3
Viral and cellular surface antigens of murine leukemias and myelomas. Serological analysis by immunoelectron microscopy.小鼠白血病和骨髓瘤的病毒及细胞表面抗原。免疫电子显微镜血清学分析。
J Exp Med. 1972 Mar 1;135(3):443-57. doi: 10.1084/jem.135.3.443.
4
Horizontal transmission of leukemia virus and leukemia in the cat.猫白血病病毒的水平传播与猫白血病
J Natl Cancer Inst. 1973 Sep;51(3):833-41. doi: 10.1093/jnci/51.3.833.
5
6
Radioimmunoassay of mammalian type-C viral proteins: interspecies antigenic reactivities of the major internal polypeptide.哺乳动物C型病毒蛋白的放射免疫测定：主要内部多肽的种间抗原反应性
Proc Natl Acad Sci U S A. 1972 Jul;69(7):1766-70. doi: 10.1073/pnas.69.7.1766.
7
Common cell-surface antigen associated with murine and feline C-type RNA leukemia viruses.与鼠类和猫科C型RNA白血病病毒相关的常见细胞表面抗原。
Proc Natl Acad Sci U S A. 1973 Jun;70(6):1878-82. doi: 10.1073/pnas.70.6.1878.
8
Tumor-specific antigen solubilized by hypertonic potassium chloride.通过高渗氯化钾溶解的肿瘤特异性抗原。
J Natl Cancer Inst. 1971 Sep;47(3):703-9.
9
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10
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J Exp Med. 1966 Oct 1;124(4):753-72. doi: 10.1084/jem.124.4.753.
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