短杆菌酪肽和线性短杆菌肽。这些肽类抗生素在芽孢形成过程中是否发挥拮抗调节作用？
Tyrocidine and the linear gramicidin. Do these peptide antibiotics play an antagonistic regulative role in sporulation?
作者信息
Ristow H, Schazschneider B, Bauer K, Kleikauf H
出版信息
Biochim Biophys Acta. 1975 May 1;390(2):246-52.
PMID:50860
Abstract
- The cyclic peptide antibiotic tyrocidine, synthesized by Bacillus brevis (ATCC 8185), inhibits RNA synthesis in an in vitro transcriptional system by forming a complex with the DNA. 2. The linear peptide antibiotic gramicidin, synthesized by the same strain, reverses at least partly this inhibition. The molecular mechanism of this reactivation is unknown. Gramicidin by itself inhibits transcription in vitro. This inhibition is not due to a complex formation between DNA and the peptide. 4. A possible regulative role of the two peptides in sporulation is discussed.
摘要
- 由短短芽孢杆菌（ATCC 8185）合成的环肽抗生素短杆菌酪肽，通过与DNA形成复合物来抑制体外转录系统中的RNA合成。2. 由同一菌株合成的线性肽抗生素短杆菌肽至少部分地逆转了这种抑制作用。这种再激活的分子机制尚不清楚。短杆菌肽本身在体外抑制转录。这种抑制并非由于DNA与该肽之间形成复合物所致。4. 讨论了这两种肽在芽孢形成中可能的调节作用。
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